Novel potent and selective dual TLR7/8 inhibitor

Novel toll-like receptor 8 (TLR8) inhibitor, potently and selectively reducing TLR8-mediated signaling

The first small molecule inhibitor of translesion synthesis (TLS) that target Rev1-CT

Potent histone methyltransferase inhibitor with rapid antimalarial activity against all blood stage forms in Plasmodium falciparum

Novel inhibitor of both JAK/STAT and proteasome activities, inducing cell death in myeloma cells

Novel inhibitor of plasminogen activator inhibitor-1 (PAI-1)

Penem beta-lactam antibiotic

Novel protease inhibitor (PI) against a variety of HIV-1 strains, including multi-PI-resistant strains, and may be less likely to generate resistance, also showing antiviral avtivity as a potential treatment for COVID-19 caused by SARS-CoV-2

Dual Inhibitor of SIRT2 Deacetylase and Defatty-Acylase Activities

Novel degrader of E. coli DHFR (eDHFR), as well as eDHFR-EGFP fusion proteins, demonstrating that degradation does not require covalent attachment of the tag to the target protein

Novel caged protein labeling agent

Allosteric agonist and positive allosteric modulator (PAM) of 5-HT3 receptor

Novel activator of necrostatin-1 sensitive necroptotic cell death, triggering apoptosis, autophagy and necroptosis crosstalk in chronic myeloid leukemia

Novel potent inhibitor of TNF-α

Novel inhibitor of tumor necrosis factor-α (TNF-α)

Emivirine analog with improved activity against drug-resistant HIV mutants

Novel non-nucleoside reverse transcriptase inhibitor of HIV-1

Novel selective inhibitor of TNKS-USP25 interaction, effectively reducing prostate cancer cell proliferation and tumor growth

Novel highly potent and selective TNKS2 inhibitor with antiproliferative effects in a colorectal cancer cell line (DLD-1) where the Wnt pathway is constitutively activated

Highly potent and selective tankyrase inhibitor

Novel potent and selective tankyrase (TNKS) inhibitor

Unique multitargeting drug conjugate with extremely low propensity for development of resistance, targeting RNA polymerase, DNA gyrase, and DNA topoisomerase IV