Potent histamine H3 receptor silent antagonist

Novel full inverse agonist at CXCR3 N3.35A

Potent H4R ligand

Novel potent ligand at 5-HT3A and 5-HT3AB receptors with different activities

VUF10497 is a potent histamine H4 receptor (H4R) inverse agonist with anti-inflammatory activity.

Potent human H4 receptor inverse agonist

Highly Potent Human Histamine H4 Receptor Inverse Agonist

Potent CXCR3 Antagonist, extending from the minor pocket into the major pocket of the transmembrane domains and binding between residues in helices 1 (Y1.39), 2 (W2.60), 3 (F3.32), 4 (D4.60), 6 (Y6.51), and 7 (S7.39, Y7.43)

First reported nonpeptidomimetic agonist on The G protein-coupled chemokine receptor CXCR3

Partial agonist in hH 4 R-mediated G protein signalling and β-arrestin2 recruitment, bounding covalently to the hH4R

Novel robust and fatigue-resistant photoswitchable GPCR antagonist

Novel robust and fatigue-resistant photoswitchable GPCR antagonist

Novel inhibitor of Hbp secretion, activating σE stress, impairing Hbp secretion and decreasing the abundance of OMPs, consistent with impaired BAM function

Novel photoswitchable modulator of the CXCR3 chemokine receptor

Novel CXCR3 ligand, photoswitching from antagonism to agonism

Novel photoswitchable modulator of the CXCR3 chemokine receptor

Histamine H3 receptor antagonist

H3R inverse agonist

Adenosine A3 receptor (A3AR) allosteric modulator

Novel full inverse agonist at CXCR3 N3.35A

Full agonist of hH4R with ~300-fold selectivity over hH3R and hH2R, but showing potent inverse agonistic activity at hH1R

Potent histamine H4 receptor full agonist