Potent, selective, and brain penetrating H2 receptor antagonist

Inhibitor of osteoclastogenesis and macrophage recruitment, decreasing bone turnover and stabilizing the bone matrix, exhibiting diverse anti-tumor effects in osteosarcoma

Gastroprotective agent for the treatment of peptic ulcer

Novel zinc sensor with a chloroalkane linker, reacting specifically with the engineered protein HaloTag, binding zinc ions with a threefold fluorescence enhancement

The first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor

Novel potentiator of KCNQ2 potassium channels

Novel COX-2 inhibitor

Antagonist of D1 and D2 dopamine receptors.

Potent, cell-permeable and irreversible caspase-1/5 inhibitor

Natural antibiotic, having diverse biological activities including broad-spectrum antibiosis against Bacteria and lower Eukarya, plant disease suppression, and enhancement of the insecticidal activity of Bacillus thuringiensis toxin against lepidopteran l

Novel multi-target inhibitor, harboring selectivity of inhibiting EGFR T790M sparing wild-type EGFR

Novel Selective Degrader of GSPT1

Novel inhibitor of Cyclophilin J (CyPJ) PPIase, demonstrating remarkable inhibition of tumor cell growth, comparable to CsA but much stronger than 5-fluorouracil

Novel inhibitor of Cyclophilin J (CyPJ) PPIase, demonstrating remarkable inhibition of tumor cell growth, comparable to CsA but much stronger than 5-fluorouracil

Cyclooxygenase-1 inhibitor

Novel next generation orally active DPP-4 inhibitor to treat Type 2 Diabetes

Novel histone deacetylase inhibitor (HDACi) with potent oral antitumor activities

Novel histone deacetylase inhibitor (HDACi) with potent oral antitumor activities

Oral active histone deacetylase inhibitor with potent antitumor activity

Novel slow H2S-NO-releasing hybrid, attenuating cardiac dysfunction after heart failure

EN171 covalently targets both C38 and C96 on 14−3−3 to enhance 14−3−3 interactions with ERα, YAP, and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity.

CNB-001 is a pyrazole derivative of curcumin with neuroprotective properties, inhibits extracellular Aβ toxicity in hippocampal neurons with EC50 of 400 nM.