DDQ is a small molecule inhibitor of binding sites of Amyloid beta (Aβ) and Drp1, reduces interaction between Aβ and Drp1, shows anti-aging effects.

MeSC-04 is a potent α-Syn amyloid formation inhibitor, reduces the number and size of amyloid fibrils in vitro.

NPT200-11 is an orally bioavailable and brain penetrating alpha-synuclein (ASYN) misfolding and aggregation inhibitor.

SRI-42667 is a selective small-molecule Tau-SH3 interaction inhibitor with IC50 of 0.91 uM (Tau-FynSH3 interaction), prevents amyloid-β toxicity and network hyperexcitability.

CC-8977 is a hgihly potent, selective inhibitor of calcium/calmodulin-dependent kinase kinase II (CaMKK2) with binding IC50 of 7 nM.

SMP-114 (Rimacalib) is a potent, specific and orally available CaMKII inhibitor with potential for treatment of rheumatoid arthritis.

BMS-332 (BMS332) is a potent, selective dual DGKα/ζ inhibitor with IC50 of 9/8 nM respectively.

BMS-684 (BMS684) is a potent, selective inhibitor of diacylglycerol kinase α(DGKα) with IC50 of 15 nM, weakly inhibist DGKβ and DGKγ, does not inhibit other DGK lipid kinases.

JNJ-3790339 is a potent and selective inhibitor of diacylglycerol kinase α (DGKα), demonstrates similar cytotoxicity in GBM and melanoma cells as ritanserin.

GRL018-21 is a highly selective, potent, and non-covalent GRK5 inhibitor with IC50 of 10 nM, >100,000-fold selectivity over GRK2.

(3S) ALG-05 is a potent pan-inhibitor of gut microbia tryptophan-indole-lyases (TILs, E.C. 4.1.99.1), exhibits inhibitory activity across TILs with Ki of 7-11 uM.

(R)-HTS-3 is a small-molecule inhibitor of LPCAT3, an integral membrane acyltransferase in the Lands cycle responsible for generating C20:4 phospholipids.

(R)-SKBG-1 is a covalent small molecule ligand of RNA-binding protein NONO, engages NONO Cys145 and suppress an array of cancer-relevant genes and impair cancer cell proliferation.

(S)-CKi-1 is a selective, covalent inhibitor of creatine kinases (CKs), inhibits recombinant creatine kinase B (CKB) phosphotransfer activity with IC50 of 0.6 uM, depletes creatine phosphagen energetics in cells.

(S)-IBD3540 is a potent, gut-restricted and orally active small molecule glutamate carboxypeptidase II (GCPII) inhibitor with IC50 of 4 nM, demonstrates anti-colitis activity in both acute and chronic mouse colitis models.

2,5-pyridinedicarboxylic acid is a highly selective D-dopachrome tautomerase (D-DT, MIF2) inhibitor with Ki of 17.2 uM, 79-fold selectivity over MIF, effectively blocks the D-DT-induced activation of CD74.

2-TCPA is a potent, specific inhibitor of carbamoyl-phosphate synthetase, aspartate transcarbamoylase, and dihydroorotase (CAD), suppresses SARS-CoV-2 replication in Caco-2 cells with IC50 of 2.36 uM.

SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK, PCK) inhibitor with Ki of 2-9 uM, an inhibitor of gluconeogenesis.

4BPPNit is a small molecule significantly augmented glycosylation of α-dystroglycan, in part through upregulation of LARGE1 glycosyltransferase gene expression.

4-Sulfonic calix[6]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release.

4-Sulfonic calix[8]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release.

5M-8OH-Q is a specific small molecule inhibitor of UDP-glucose glycoprotein glucosyltransferase (UGGT), binds a CtUGGTGT24 “WY” conserved surface motif conserved across UGGTs (Kd=47 uM) but not present in other GT24 family glycosyltransferases.