Cat. No. | Product name | CAS No. |
DC66454 |
Melanotan I acetate
Featured
Melanotan I acetate is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I acetate is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I acetate can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I acetate can be used for sunlight-induced skin cancers research. |
1566590-77-9 |
DC60599 |
G-5758
Featured
G-5758 is a potent, selective, and orally available IRE1α inhibitor with IC50 of 38 nM in XBP1s reporter assay. G-5758 demonstrates a robust PD response in the KMS-11 tumor xenograft model. |
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DC60600 |
PFI-7
Featured
PFI-7 is a potent, selective and cell-active chemical probe that antagonizes Pro/N-degron binding to human GID4 with Kd of 79 nM. PFI-7 will be a valuable research tool for investigating CTLH complex biology and facilitating development of targeted protein degradation strategies that highjack CTLH E3 ligase activity. |
|
DC60601 |
GLP-1-MK-801
Featured
GLP-1-MK-801 is a GLP-1-directed NMDA receptor antagonist for targeting to achieve cell-specifc ionotropic receptor modulation and highlights the therapeutic potential of unimolecular mixed GLP-1 receptor agonism and NMDA receptor antagonism. |
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DC60602 |
Jun12682
Featured
Jun12682 is a SARS-CoV-2 papain-like protease (PLpro) inhibitor with Ki of 37.7 nM and displays EC50 of 1.1 μM in the FlipGFP PLpro assay, more than 20-fold improved from GRL0617 (EC50=22.4 μM). |
|
DC66455 | Stanolone Featured | 521-18-6 |
DC60603 |
O12-D3-I3
Featured
O12-D3-I3 is an imidazole-based lipid for siRNA delivery. O12-D3-I3-LNPs encapsulating FVII siRNA (FVII@O-LNP) elicites greater gene silencing than those with the DLin-MC3-DMA (MC3) due to its stronger endosomal escape. |
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DC60604 |
CDD-2807
Featured
CDD-2807 is a potent serine/threonine kinase 33 (STK33) inhibitor with Kd of 0.02 nM and IC50 of 9.2 nM, respectively. CDD-2807 shows >9-fold selectivity versus other kinases and demonstrates excellent metabolic stability with T1/2 >60 min in MLM and HLM. |
|
DC60605 |
Lipid 119-23
Featured
Lipid 119-23 is an ionizable lipid for mRNA delivery. 119-23 LNP exhibits an enhanced capability to express functional mCre in several categories of immune cells, spanning the liver, spleen and lung. |
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DC60606 |
KL-50
Featured
KL-50 is a selective toxin toward tumors that lack the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O6-alkylguanine lesions. KL-50 is the first reported compound to overcome acquired temozolomide resistance while maintaining high selectivity for MGMT-cells. |
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DC60607 |
SL-25.1188
Featured
SL-25.1188 is a monoamine oxidase B (MAO-B) inhibitor potentially for treatment of Alzheimer's dementia and smoking cessation. SL-25.1188 is characterized in vivo by reversible binding, high brain uptake, and very slow plasma metabolism. |
185835-97-6 |
DC66456 |
TLR7/8 agonist 1
Featured
TLR7/8 agonist 1 is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline. |
1258457-59-8 |
DC66457 |
FAP-IN-2 (FAPI)
Featured
FAP-IN-2 is a derivative of 99mTc-labeled isonitrile-containing fibroblast activation protein (FAPI) inhibitor, that can be used for tumor imaging. |
|
DC66458 | FAPI -14 Featured | 2374782-82-6 |
DC60608 |
SL25.1188 precursor
Featured
SL25.1188 precursor is the precursor of SL25.1188. |
1114325-79-9 |
DC66459 |
NOTA-FAPI
Featured
NOTA-FAPI is a fibroblast activation protein (FAP) inhibitor. NOTA-FAPI can be used as a probe for FAP-targeted tumour imaging. NOTA-FAPI has good tumour detection efficacy and excellent imaging quality. |
2374782-03-1 |
DC66460 |
FAPI-4
Featured
FAPI-4 is a potent fibroblast activation protein (FAP) inhibitor for the targeting FAP. FAPI-4 can be used in cancer research. 68Ga-FAPI-4 PET/CT is a promising new diagnostic method for imaging various kinds of cancer, with good tumor-to-background contrast ratios. |
2374782-02-0 |
DC66461 | SH-FAPI-4 Featured | |
DC66462 |
HYINC-FAPI-4
Featured
HYINC-FAPI-4 is a derivative of 99mTc-labeled isonitrile-containing fibroblast activation protein (FAPI) inhibitor, that can be used for tumor imaging. |
2471983-20-5 |
DC66463 | FAPI-46-NOTA Featured | |
DC66464 |
3BP-3940
Featured
3BP-3940 is a highly potent fibroblast activation protein (FAP)-targeting peptide for theranostics. 3BP-3940 is often coupled with radionuclides for tumor diagnosis and treatment. |
2803421-14-7 |
DC66465 |
Pentanedioate
Featured
Pentanedioate is a starting material for the synthesis of specific PSMAM inhibitors. |
1025796-31-9 |