Azido-PEG10-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG2-C6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propanol-PEG4-CH2OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propanol-PEG5-CH2OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyloxy-C5-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG2-ethoxyethane-PEG2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Hydroxy-PEG2-CH2CH2COO-PEG2-propionic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Dimethylamino-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Ph-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-C4-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

I-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bromo-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG9-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Dimethylamino-PEG11 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG11-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG11-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG13-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG14-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Hydroxy-PEG14-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG15-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-PEG16-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG16-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG18-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG20-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG24-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG36-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Hydroxy-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Thiol-PEG-COOH (MW 5000) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Amino-PEG4-C2-SH hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Amine-PEG6-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Amino-PEG7-C2-SH hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Desmethyl-QCA276 (PROTAC BRD4-binding moiety 4), the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM.

SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF TFA can be used in the synthesis of PROTAC.

F-PEG2-S-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Boc-NH-PEG12-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

m-PEG8-amide-C10-Thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-PEG1-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Thiol-PEG4-amide-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Thiol-C9-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG4-Thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

NHS-bis-PEG2-amide-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bis-(Mal-PEG3)-PH-N-succinimidyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG4-acyl chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

NHS ester-PEG7-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

NHS ester-PEG10-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

NHS ester-PEG13-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Iodoacetamido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Mal-PEG12-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

F-PEG2-S-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

F-PEG2-SO-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

F-PEG2-SO2-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bromo-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bromo-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

VES-POFP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Amino-PEG2-CH2CH2-SH (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bromo-PEG10-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bromo-PEG12-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Biotin-PEG3-methyl ethanethioate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Biotin-PEG3-pyridinrthiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Biotin-PEG2-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Fmoc-N-amido-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

NHS ester-PEG3-S-methyl ethanethioate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Fmoc-N-amido-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bromo-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG4-acyl chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG8-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Br-PEG7-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

CG-PEG5-azido is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

CH2COOH-PEG12-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Desthiobiotin-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

NH2-PEG3500-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Fmoc-NH-PEG3-amide-CH2OCH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

PEG2-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Trt-PEG4-C2-acid (hydrate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

CH2COOH-PEG6-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Nonylbenzene-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Biotin-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Tetraethylene glycol monohexadecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Fmoc-N-amido-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Ethyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

t-Butyl acetate-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Methyl-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

endo-BCN-PEG2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-PEG1-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Methyl-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Cl-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-CH3-ethyl propionate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

Thiol-C10-amide-PEG8 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Thiol-C9-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Thiol-C9-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

5-[Boc(methyl)amino]pentanal is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG3-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Thiol-C9-PEG7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

CH2COOH-PEG9-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bis-PEG2-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

Biotin-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

F-PEG2-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Boc-NH-PPG2 is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

HO-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG2-urea-C3-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Boc-NHCH2CH2-PEG1-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Biotin-PEG3-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Fmoc-N-amido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

MS-PEG3-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG7-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG6-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bis-CH2-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Amino-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Thiol-PEG2-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Methyl-PEG4-acyl chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG9-S-methyl ethanethioate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG5-S-methyl ethanethioate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Methyl-PEG3-Ald is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Thiol-C9-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Nonylbenzene-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bromo-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

t-Butyl acetate-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Cyclohexane-PEG1-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

BocNH-PEG5-CH2CH2Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Tos-PEG3-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

XD2-149 is a napabucasin PROTAC as an effective degrader of the E3 ligase ZFP91 with IC50 of 1 μM and 0.8 μM in pancreatic cancer cell lines, MIA PaCa-2 and BxPC-3, respectively. XD2-149 also reduces the expression of STAT3, pSTAT3, and NQO1 proteins.

ARV-110 is an orally active, specific androgen receptor (AR) PROTAC degrader. ARV-110 promotes ubiquitination and degradation of AR. ARV-110 can be used for the research of prostate cancer.

ARV-471 is a best-in-class, orally active estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.

PROTAC BRD4 Degrader-10 (compound 8b) is a potent BRD4 degrader. PROTAC BRD4 Degrader-10 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 1.3 nM and 18 nM, respectively.

PROTAC BRD4 Degrader-12 (compound 9c) is a potent chimeric BRD4 degrader. PROTAC BRD4 Degrader-12 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.39 nM and 0.24 nM, respectively.

PROTAC BRD4 Degrader-13 (compound 9d) is a potent chimeric BRD4 degrader. PROTAC BRD4 Degrader-13 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.025 nM and 6.0 nM, respectively.

PROTAC BRD4 Degrader-11 (compound 9a) is a potent chimeric BRD4 degrader. PROTAC BRD4 Degrader-11 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.23 nM and 0.38 nM, respectively.

PROTAC BRD4 Degrader-14 is a potent BRD4 degrader, with IC50s of 1.8 nM and 1.7 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-14 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells.

PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells.

PROTAC BRD4 Degrader-9 (compound 8a) is a potent BRD4 degrader. PROTAC BRD4 Degrader-9 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.86 nM and 7.6 nM, respectively.

Bis-sulfone-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

m-PEG5-Propyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

S-acetyl-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

S-acetyl-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG5-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Mal-amido-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

S-acetyl-PEG4-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Pyrene azide 3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Mal-amido-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

(E)-TCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG12-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG9-Ots is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Mal-amido-PEG9-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Biotin-PEG3-Bis-sulfone is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

PC DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Mal-C2-cyclohexylcarboxyl-hydrazide hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Benzyl-PEG4-Azido is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Benzyl-PEG4-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

m-PEG9-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Azido-PEG8-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Benzyl-PEG5-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Benzyl-PEG6-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Azido-PEG8-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Benzyl-PEG7-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Benzyl-PEG8-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

m-PEG13-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

DBCO-PEG13-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

S-acetyl-PEG4-Thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

m-PEG5-amino-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG7-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Mal-amido-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG7-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG11-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Mal-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG13-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Mal-amido-PEG7-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Mal-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Mal-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG13-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

m-PEG14-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Fmoc-PEG9-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Fmoc-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bis-sulfone-PEG4-Tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG10-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG10-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Benzyl-PEG12-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

XY028-140 (MS-140) is a potent and selective PROTAC-based CDK4/CDK6 kinase degrader. XY028-140 specifically inhibits RB-E2F signaling and reduces CDK4 and CDK6 protein levels in a dose- and time-dependent manner in vitro. In addition, XY028-140 can degrade its targets by linking them with ubiquitin-proteasome mechanism. Further, the degradation of CDK4/6 protein by XY028-140 is specifically mediated by CRBN. Therefore, XY028-140 effectively and selectively inhibits and degrades CDK4/6 kinase by targeting CDK4/6 kinase in CDK4/6i-S (CDK4/6 inhibitor-sensitive) tumor cells to the CRL4-CRBN-E3 ubiquitin complex. Compared with CDK6 wild-type cells, XY028-140 treatment of cells expressing wild-type or mutation-activated CDK6 resulted in a more effective degradation of CDK6 (S178P).

ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis.

Bis-PEG12-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

5-Boc-amino-pentanoic acid (Boc-5-aminovaleric acid, Boc-NH-C4-acid, Boc-5-Ava-OH) is a PROTAC linker that belongs to a Alkyl/ether linker. Boc-NH-C4-acid is applicable to the synthesis of PROTAC1, and specifically degrades EED, EZH2, and SUZ12 in the PRC2 Complex.

PROTAC BRD4 Degrader-15 is a potent BRD4 degrader, with IC50s of 7.2 nM and 8.1 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-15 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells.

PROTAC IRAK4 degrader-4 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-127.

PROTAC IRAK4 degrader-6 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-172.

PROTAC KRAS G12C degrader-1 is a PROTAC-based KRASG12C degrader, with an IC50 of 414 nM for CRBN. PROTAC KRAS G12C degrader-1 induces CRBN/ KRASG12C dimerization and degrades GFP- KRASG12C in reporter cells.