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18:0 DAP

  Cat. No.:  DC49239  
Chemical Structure
121315-93-3
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More than 5000 active chemicals with high quality for research!
Field of application
18:0 DAP can be used to formulate lipid nanoparticles (LNPs), which mRNA is encapsulated in their core.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 121315-93-3
Chemical Name: [3-(Dimethylamino)-2-octadecanoyloxypropyl] octadecanoate
Synonyms: 3-(Dimethylamino)propane-1,2-diyl distearate;[3-(dimethylamino)-2-octadecanoyloxypropyl] octadecanoate;18:0 DAP, 1,2-distearoyl-3-dimethylammonium-propane, powder;18:0 DAP, 1,2-distearoyl-3-dimethylammonium-propane, chloroform
SMILES: O(C(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=O)C([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=O
Formula: C41H81NO4
M.Wt: 652.0862
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_33138_DC49239_121315-93-3
COA
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Cat. No. Product name Field of application
DC72546 Tri-GalNAc-NHS ester Tri-GalNAc-NHS ester is a LYsosome TArgeting Chimera (LYTAC) and a ligand of asialoglycoprotein receptor (ASGPR). ASGPR is a lysosomal targeting receptor specifically expressed on liver cells, for the degradation of extracellular proteins including membrane proteins. Tri-GalNAc-NHS ester can be used as a protein degrader and it can be used for the research of LYTAC.
DC72426 DSPE-SPDP DSPE-SPDP is a phospholipid molecule. DSPE-SPDP can orient itself to form lipid bilayer in water. DSPE-SPDP can be used for the research of various biochemical.
DC71044 Fluorescent DOTAP Fluorescent DOTAP, a cationic lipid, can be used for the research of nucleic acid and protein delivery.
DC70010 98N12-5 98N12-5 is an ionizable cationic lipid. It has been used in combination with other lipids in the generation of lipid nanoparticles (LNPs). LNPs containing 98N12-5 and encapsulating proprotein convertase subtilisin kexin type 9 (PCSK9) siRNA selectively accumulate in the liver and reduce total serum cholesterol levels in mice and rats and serum LDL levels in cynomolgus monkeys.
DC49961 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) sodium salt is a lipid molecule having one negative charge, which can interact with the positive charges of peptides.
DC49882 CKK-E12 CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based therapeutics. cKK-E12 was highly selective toward liver parenchymal cell in vivo.Multitail lipids usually have three or more tails and tend to form more cone-shaped structures due to the increase of tail crosssection, which enhances the endosome escape and mRNA delivery efficiency.CKK-E12 is an ionizable lipid with four lipid tails and diketopiperazine core-based head. It has shown excellent efficiency in delivering CRISPR-Cas9 mRNA and sgRNA.cKK-E12 iLNPs encapsulated mRNA was used to investigate the effect of Toll-like receptor 4 (TLR4) on iLNPsmediated mRNA delivery, and it has been demonstrated that the targeting, safety and efficacy of iLNPs are closely related to disease state. In other words, even though iLNP delivers therapeutic mRNA to a given cell type in one disease state, it is not guaranteed to deliver mRNA to the same cell type in another disease. As same as MC3 and C12-200, CKK-E12 is also used to be a positive control ionizable lipid when exploiting new ionizable lipids.
DC49249 DOPS-NA DOPS-NA is a ubstitute for Phosphoserine/phosphatidylserine. DOPS-NA can be used in lipid mixtures with DOPC and DOPE as effective nontoxic and nonviral DNA vectors.
DC49239 18:0 DAP 18:0 DAP can be used to formulate lipid nanoparticles (LNPs), which mRNA is encapsulated in their core.
DC47310 Rovanersen Rovanersen (WVE-120101) is an antisense oligonucleotide that can be used for huntington’s disease research.
DC47285 Tofersen Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS).
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