Tri-GalNAc-NHS ester
Cat. No.: DC72546
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Chemical Structure
1953146-83-2
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Field of application
Tri-GalNAc-NHS ester is a LYsosome TArgeting Chimera (LYTAC) and a ligand of asialoglycoprotein receptor (ASGPR). ASGPR is a lysosomal targeting receptor specifically expressed on liver cells, for the degradation of extracellular proteins including membrane proteins. Tri-GalNAc-NHS ester can be used as a protein degrader and it can be used for the research of LYTAC.
| Cas No.: |
1953146-83-2 |
| Chemical Name: |
Tri-GalNAc-NHS ester |
| SMILES: |
O=C(CCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)NC(COCCC(NCCCNC(CCCCO[C@H](O[C@@H]2CO)[C@@H]([C@H]([C@H]2O)O)NC(C)=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@H](O[C@@H]3CO)[C@@H]([C@H]([C@H]3O)O)NC(C)=O)=O)=O)COCCC(NCCCNC(CCCCO[C@H](O[C@@H]4CO)[C@@H]([C@H]([C@H]4O)O)NC(C)=O) |
| Formula: |
C79H137N11O37 |
| M.Wt: |
1832.98 |
| Purity: |
>95% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Publication: |
[1]. Zhou Y, et al. Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins. ACS Cent Sci. 2021 Mar 24;7(3):499-506. |
| Description: |
Tri-GalNAc-NHS ester is a LYsosome TArgeting Chimera (LYTAC) and a ligand of asialoglycoprotein receptor (ASGPR). ASGPR is a lysosomal targeting receptor specifically expressed on liver cells, for the degradation of extracellular proteins including membrane proteins. Tri-GalNAc-NHS ester can be used as a protein degrader and it can be used for the research of LYTAC. |
| References: |
[1]. Zhou Y, et al. Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins. ACS Cent Sci. 2021 Mar 24;7(3):499-506. |
MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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