| Cas No.: | 2072901-32-5 |
| Chemical Name: | Rovanersen |
| Synonyms: | WVE-120101 |
| M.Wt: | 6617.00 |
| Purity: | >95% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Target: | HTT |
| In Vivo: | In non-human primates (NHPs), Rovanersen (WVE-120101) is found in nuclear and perinuclear compartments of neurons in brain areas believed to be involved in HD pathology. |
| In Vitro: | In vitro, Rovanersen (WVE-120101) leads to the selective RNase H cleavage of mutant Huntingtin allele (mHTT) over wtHTT, with no complement activation. Rovanersen selectively decreases mHTT mRNA and protein levels compared with wtHTT in multiple cells lines. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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