Cat. No. | Product name | CAS No. |
DC3145 |
Sunitinib base
Featured
Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. |
557795-19-4 |
DC8852 |
SW-044248
Featured
SW-044248 is a Novel Inhibitor of Topoisomerase I Is Selectively Toxic for a Subset of Non-Small Cell Lung Cancer Cell Lines. |
522650-83-5 |
DC9311 |
Serabelisib(TAK-117,INK1117,MLN1117)
Featured
TAK-117(INK1117,MLN1117) is an orally bioavailable inhibitor of the class I phosphoinositide 3-kinase (PI3K) alpha isoform with potential antineoplastic activity. |
1268454-23-4 |
DC11633 |
TAK-243
Featured
TAK-243 (MLN-7243, AOB87172) is a small-molecule, cell-permeable inhibitor of ubiquitin-activating enzyme E1 (UAE1). |
1450833-55-2 |
DC10523 |
TAK-659 HCl
Featured
TAK-659 hydrochloride is a potent, selective and orally available spleen tyrosine kinase (Syk) inhibitor with an IC50 of 3.2 nM. |
1952251-28-3 |
DC7308 |
TAK-733
Featured
TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc. |
1035555-63-5 |
DC11370 |
TAK-901
TAK-901 is a non-selective Aurora kinase inhibitor (IC50s = 3.1, 10, and 4.2 nM for Aurora A, B, and C, respectively). |
934541-31-8 |
DC8739 |
Talabostat mesylate
Talabostat mesilate(PT-100; Val-boroPro) is an orally active, specific inhibitor of dipeptidyl peptidases(IC50=1 nM for DPP4), including tumor-associated fibroblast activation protein. |
150080-09-4 |
DC7894 |
Tandutinib(MLN518)
Tandutinib (MLN518, CT53518) is a potent FLT3 antagonist with IC50 of 0.22 μM, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR. Phase 2. |
387867-13-2 |
DC7769 |
Tanomastat
Tanomastat is an angiogenesis and Matrix Metalloproteinase inhibitor |
179545-77-8 |
DC1102 |
Tariquidar (XR9576)
Featured
Tariquidar (XR9576) is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM. |
206873-63-4 |
DC7312 |
Tasisulam(LY573636)
Featured
Tasisulam sodium is The sodium salt of an acyl-sulfonamide with potential antineoplastic activity. |
519055-62-0 |
DC7733 |
Tasquinimod(ABR-215050)
Featured
Tasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. |
254964-60-8 |
DC8962 |
Tegafur
Featured
Tegafur (also known as Ftorafur) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers; is a component of tegafur-uracil. |
17902-23-7 |
DC9586 |
Telatinib
Featured
Telatinib(Bay 57-9352) is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRα with IC50 of 6 nM/4 nM, 1 nM and 15 nM, respectively. |
332012-40-5 |
DC10150 |
Tenalisib
Tenalisib (RP6530) is a novel, potent, and selective PI3Kδ and PI3Kγ inhibitor with IC50 values of 25 and 33 nM, respectively. |
1639417-53-0 |
DC7317 |
TG101209
Featured
TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, ~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations; TG101209 inhibit BRD4 activity with IC50 of 130 nM. |
936091-14-4 |
DC7318 |
TG101348(Fedratinib)
Featured
TG-101348 (SAR302503) is a selective inhibitor of JAK2 with IC50 of 3 nM, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3, TG-101348 also inhibit BRD4 with IC50 of 340 nM. |
936091-26-8 |
DC8652 |
TGR-1202 hydrochloride(Umbralisib)
TGR-1202 hydrochloride is an orally available, next generation PI3Kdelta inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 and 24.3 nM respectively. |
1532533-78-0 |
DC8653 |
TGR-1202(Umbralisib)
Featured
TGR-1202 is an orally available, next generation PI3Kdelta inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 and 24.3 nM respectively. |
1532533-67-7 |
DC7689 |
Evofosfamide(TH-302)
Featured
TH-302 is selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism. |
918633-87-1 |
DC11492 |
GMX-1777 chloride
The water-soluble prodrug of GMX-1778 (CHS-828), which is a potent and specific inhibitor of the NAD(+) biosynthesis enzyme NAMPT with IC50 of <20 nM. |
432037-57-5 |