Cat. No. | Product name | CAS No. |
DC5192 |
TIC10 isomer
TIC10 isomer(ONC201 isomer) is an isomer of TIC10; TIC10 is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. |
41276-02-2 |
DC10478 |
Tinostamustine(EDO-S101)
Featured
Tinostamustine is the first representative of the A-DAC principle, a new approach in chemotherapy that uses fusion technology to combine an alkylating agent with a pan-histone deacetylase inhibitor (HDAC) to simultaneously damage DNA and block damage repa |
1236199-60-2 |
DC9701 |
Tipifarnib
Featured
Tipifarnib (IND 58359; R115777) is a potent and specific farnesyltransferase inhibitor with an IC50 of 0.6 nM. |
192185-72-1 |
DC7065 |
Tivantinib (ARQ 197)
Featured
Tivantinib (ARQ 197) is the first non-ATP-competitive c-Met inhibitor with Ki of 0.355 μM, little activity to Ron, and no inhibition to EGFR, InsR, PDGFRα or FGFR1/4. |
905854-02-6 |
DC5078 |
Tivozanib(AV-951)
Featured
Tivozanib (AV-951, KRN-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 0.21 nM/0.16 nM/0.24 nM, and also inhibits PDGFR and c-Kit, low activity observed against FGFR-1, Flt3, c-Met EGFR and IGF-1R. |
475108-18-0 |
DC8008 |
TOK-001(Galeterone)
Featured
TOK-001 is a multifunctional antiandrogen and CYP17 inhibitor(IC50=47 nM) in castration resistant prostate cancer (CRPC). |
851983-85-2 |
DC8223 |
TP-0903
Featured
TP-0903 is a a high-affinity Axl inhibitor with IC50 of 27 nM. |
1341200-45-0 |
DC10611 |
Trabectedin
Featured
Trabectedin (Ecteinascidin-743 or ET-743) is a novel antitumour agent of marine origin with potent antitumour activity both in vitro and in vivo. |
114899-77-3 |
DC1099 |
Trametinib
Featured
Trametinib is a highly specific and potent MEK1 and MEK2 inhibitor with IC50 of 0.92 nM and 1.8 nM, respectively. |
871700-17-3 |
DC7522 |
Triapine
Featured
Triapine is a potent ribonucleotide reductase inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2. |
143621-35-6 |
DC12037 |
Triptolide
Featured
Triptolide is the major bioactive constituent of T. wilfordii Hook F., also known as thunder god vine, a traditional Chinese medicinal herb with known antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and anti-polycystic kidney disea |
38748-32-2 |
DC11087 |
TRX-818 sodium
TRX-818 sodium (Foslinanib sodium ) is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities, induces cancer cell apoptosis and inhibits cancer cell proliferation. |
1256037-62-3 |
DC8272 |
U-104
Featured
U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM; low inhibition for CA I and CA II. |
178606-66-1 |
DC9813 |
Valspodar(PSC833)
Featured
Valspodar(PSC833) is a P-glycoprotein (P-gp) inhibitor widely used in preclinical and clinical studies for overcoming multidrug resistance (MDR). |
121584-18-7 |
DC3134 |
Vandetanib (ZD6474)
Featured
Vandetanib (Zactima, ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM. |
443913-73-3 |
DC7607 |
Vatalanib
Featured
Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM, less potent against VEGFR1/Flt-1, 18-fold against VEGFR3/Flt-4. Phase 1/2. |
212141-51-0 |
DC8655 |
Vatalanib free base
Vatalanib free base (PTK787 free base) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM, less potent against VEGFR1/Flt-1, 18-fold against VEGFR3/Flt-4. |
212141-54-3 |
DC8899 |
ABT888 (free base)
Featured
Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively. |
912444-00-9 |
DC5150 |
Veliparib (ABT-888 hydrochloride)
Featured
Veliparib is a potent inhibitor of both PARP-1 and PARP-2 by [3H]NAD+ with Kis of 5.2 and 2.9 nmol/L, respectively. |
912445-05-7 |
DC4184 |
Vinorelbine Ditartrate
Featured
Vinorelbine (Navelbine) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM. |
125317-39-7 |
DC4232 |
Vismodegib (GDC-0449)
Featured
Vismodegib (formerly GDC-0449) is a hedgehog antagonist, is also an orally bioavailable small molecule with potential antineoplastic activity. |
879085-55-9 |
DC10642 |
VLX1570
VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10 μM in vitro. |
1431280-51-1 |