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| Cas No.: | 519055-62-0 |
| Chemical Name: | Tasisulam |
| Synonyms: | Tasisulam;N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide;LY573636;N-(5-bromothiophen-2-yl)sulfonyl-2,4-dichlorobenzamide;N-(5-Bromothiophen-2-ylsulfonyl)-2,4-dichlorobenzamide;UNII-1YC4W9MSLJ;1YC4W9MSLJ;519055-62-0;DTXSID20199869;FT-0763021;AS-38576;HY-14804;AC-32975;P7M;Tasisulam(LY573636);Tasisulam [INN];J-522818;EX-A1367;Q27253184;SW219181-1;CCG-268827;HMS3653O12;BCP05154;s7326;NCGC00386305-05;LY 573636 (sodium);Benzamide, N-((5-bromo-2-thienyl)sulfonyl)-2,4-dichloro-;BCP9000890;NS00069285;519055-63-1;SB19401;CHEMBL2110587;Z442229142;Tasisulam (sodium);AKOS027250790;N-((5-BROMOTHIOPHEN-2-YL)SULFONYL)-2,4-DICHLOROBENZAMIDE;N-[(5-bromothiophen-2-yl)sulfonyl]-2,4-dichlorobenzamide;TASISULAM [WHO-DD];SCHEMBL1581371;Tasisulam (LY573636);LY-573636;DB11941;CS-0003569;LY 573636;MFCD11973637;EN300-6492968;Tasisulam(LY573636)?;CHEBI:231621;tasisulamum;DB-071449;LY573636 sodium;DTXCID30122360;BRD-K42495768-001-01-7;n-((5-bromo-2-thienyl)sulfonyl)-2,4-dichlorobenzamide |
| SMILES: | O=C(NS(=O)(C1=CC=C(Br)S1)=O)C2=CC=C(Cl)C=C2Cl |
| Formula: | C11H6NO3S2Cl2Br |
| M.Wt: | 415.11024 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Tasisulam is a small molecule antitumor agent that inhibits mitotic progression and induces vascular normalization. Tasisulam induces apoptosis via the intrinsic pathway[1]. |
| In Vitro: | Tasisulam (200 μM-200 nM; 48 hours) induces an antiproliferative response across a wide range of tumor histologies with EC50s is 10 μM and 25 μM for Calu-6 and A-375 cell lines, respectively[1]. Tasisulam (25, 50 μM; 72 hours) induces a concentration-dependent increase in 4N DNA and G2-M accumulation[1]. Tasisulam (200 μM-200 nM; 48 hours) induces apoptosis in a broad range of in vitro cancer cell models[1]. Cell Proliferation Assay[1] Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 μM-200 nM Incubation Time: 48 hours Result: Induced an antiproliferative response across a wide range of tumor histologies with EC50s are 10 μM and 25 μM, respectively. Cell Cycle Analysis[1] Cell Line: Calu-6 and A-375 cell lines Concentration: 25, 50 μM Incubation Time: 72 hours Result: Induced a concentration-dependent increase in 4N DNA and G2-M accumulation. Apoptosis Analysis[1] Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 μM-200 nM Incubation Time: 48 hours Result: Induced apoptosis in a broad range of in vitro cancer cell models. |