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| Cas No.: | 41276-02-2 |
| Chemical Name: | TIC-10 Isomer |
| Synonyms: | TIC-10; TIC 10; TIC10 |
| SMILES: | O=C(C(C1)=C(N2CC3=C(C)C=CC=C3)CCN1CC4=CC=CC=C4)N5C2=NCC5 |
| Formula: | C24H26N4O |
| M.Wt: | 386.489 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal-regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. TIC10 is an efficacious antitumor therapeutic agent that acts on tumor cells and their microenvironment to enhance the concentrations of the endogenous tumor suppressor TRAIL. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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