1,2(R)-Dioleyloxy-3-dimethylamino-propane ((R)-DODMA) is an ionizable cationic lipid and an isomer of DODMA

306Oi9-cis2 is an ionizable cationic lipid. WARNING This product is not for human or veterinary use.

Lipid AX4 is an ionizable cationic lipid (pKa = 6.89) that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.

RM 137-15 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 LNPs containing RM 137-15 and encapsulating mRNA encoding a fluorescent reporter increase fluorescence in the livers of mice.

C12-SPM is a polyamine branched-chain lipidoid.1 It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of siRNA targeting the host protein kinase protein kinase C-related kinase 2 (PRK2) to inhibit hepatitis C virus (HCV) replication in Huh7 cells and a mouse model of HCV infection.

C14-SPM is a polyamine branched-chain lipidoid.1 It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of siRNA.

Lipid C14-A1 is an ionizable lipid. C14-A1-LPN is a potent and safe LNP platform to deliver Foxp3 mRNA to CD4+ T cells to engineer immunosuppressive FP3T cells.

Lipid C12-A1 is an ionizable lipid. C12-A1-LPN is a potent and safe LNP platform to deliver Foxp3 mRNA to CD4+ T cells to engineer immunosuppressive FP3T cells. C12-A1 has a slightly lower average cell viability than C14-A1.

Lipid 2-10 is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure.

RCB-4-8 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA.1 RCB-4-8-containing LNPs improve lung transfection efficiency by approximately 100-fold over MC3-containing LNPs in mice.

IR-19-Py(A20-0l) is an ionizable, degradable lipid for nebulized mRNA delivery.

IR-117-17(A10-LIN) is an ionizable, degradable lipid for nebulized mRNA delivery. Nebulized IR-117-17 LNPs produced a 300-fold improvement in lung mRNA delivery over the top previously described LNP. and a two-fold improvement over the previously reported PBAE, including up to a 45-fold improvement in delivery to the large airways.

4A3-SCC-10 is a biodegradable ionizable lipid with superior endosomal escape and rapid mRNA release ability. In comparison with DLin-MC3-DMA, 4A3-SCC-10-formulated LNPs significantly improve mRNA delivery in livers by 87-fold.

4A3-SCC-PH is a biodegradable ionizable lipid with superior endosomal escape and rapid mRNA release ability. In comparison with DLin-MC3-DMA, 4A3-SCC-PH-formulated LNPs significantly improve mRNA delivery in livers by 176-fold. 4A3-SCC-PH enhance Fluc mRNA release and luciferase expression in tumor cells, further assisting cancer metastasis delineation and surgical resection.

L-369 (Lipid 369,L369) is novel class of ionizable lipid for siRNA delivery with improved in vivo elimination profile with excellent translation across species,including NHP, wide safety margin.

Iso-A11B5C1 is an ionizable lipid. The iso-A11B5C1 LNP demonstrates a high level of muscle-specific mRNA delivery efficiency. exhibiting transfection efficiency comparable to the commercially available lipid SM-102, while considerably reducing inadvertent mRNA expression in main organs such as the liver and spleen.Additionally, study results show that intramuscular administration of mRNA formulated with iso-A11B5C1 LNP caused potent cellular immune responses, even with limited expression observed in lymph nodes.

DSPE-MPEG(5000) is a PEGylated form of 1,2-distearoyl-rac-glycero-3-PE (DSPE). It has been used in the synthesis of lipid nanoparticles (LNPs) and liposomes for in vitro and in vivo two-photon bioimaging.

DPPE is a derivative of phosphatidylethanolamine with (16:0) palmitoyl acyl chains

1-Palmitoyl-sn-glycero-3-phosphocholine is an abundant gonadal LPC (lysophosphatidylcholine).