Iso-A11B5C1| ionizable lipid |DC Chemicals

Cas No.:
Chemical Name:	Iso-A11B5C1
Formula:	C₄₁H₇₉N₃O₃
M.Wt:	663.10
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects--Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):Jingan Chen ,Bowen Li

Description:

Iso-A11B5C1 is an ionizable lipid. The iso-A11B5C1 LNP demonstrates a high level of muscle-specific mRNA delivery efficiency. exhibiting transfection efficiency comparable to the commercially available lipid SM-102, while considerably reducing inadvertent mRNA expression in main organs such as the liver and spleen.Additionally, study results show that intramuscular administration of mRNA formulated with iso-A11B5C1 LNP caused potent cellular immune responses, even with limited expression observed in lymph nodes.

References:

Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects--Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):Jingan Chen ,Bowen Li

MSDS

Cat. No.	Product name	Field of application
DC60510	Iso-A11B5C1	Iso-A11B5C1 is an ionizable lipid. The iso-A11B5C1 LNP demonstrates a high level of muscle-specific mRNA delivery efficiency. exhibiting transfection efficiency comparable to the commercially available lipid SM-102, while considerably reducing inadvertent mRNA expression in main organs such as the liver and spleen.Additionally, study results show that intramuscular administration of mRNA formulated with iso-A11B5C1 LNP caused potent cellular immune responses, even with limited expression observed in lymph nodes.
DC65680	Lipid 2-10	Lipid 2-10, an ionizable lipid with a pKa of 6.16, is utilized in the formulation of lipid nanoparticles (LNPs) featuring a bilayer structure.