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Inflammation/Autoimmune Disease

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Cat. No. Product Name Field of Application Chemical Structure
DCAPI1355 Loteprednol etabonate Loteprednol etabonate
DC9011 Mizoribine Featured Mizoribine(NSC 289637; HE 69; β-Bredinin) is an immunosuppressive agents (IC50=100 uM) that inhibit the proliferation of lymphocytes selectively, via inhibition of IMPDH.
DC3167 MK0812 MK-0812 is chemokine receptor CCR-2 antagonist
DC9279 MK-571 Featured MK-571 is a selective, orally active CysLT1 receptor antagonist.
DC9448 MK591 MK591(Quiflapon sodium) is a selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor.
DC3160 Montelukast Sodium Featured Montelukast belongs to a group of medications known as leukotriene receptor antagonists.
DC7471 N6022 Featured N6022 is a potent, selective, reversible, and efficacious S-Nitrosoglutathione reductase(GSNOR) inhibitor(IC50=10 nM) which is currently undergoing clinical development.
DC7472 Nedocromil Nedocromil is an inhaled anti-inflammatory agent for the preventive management of asthma.
DC9583 Oglemilast Featured Oglemilast(GRC3886) is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma.
DC10384 Olodaterol Featured Olodaterol (BI1744) is a long acting β2-adrenoceptor agonist with an EC50 of 1.4±0.08 nM.
DC9248 Olodaterol(BI-1744) hydrochloride Featured Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs.
DC8281 Ozanimod (RPC1063) Featured Ozanimod (RPC1063) is a selective S1P1R modulator
DC10399 PAC-14028 PAC-14028 is a potent and selective transient receptor potential vanilloid type I (TRPV1) antagonist.
DC9681 Pamapimod(R-1503) Featured Pamapimod(R-1503)is a novel p38 MAP kinase inhibitor.
DC10893 Parimifasor Featured Parimifasor is an immunomodulator, with anti-inflammatory activity.
DC8168 Peficitinib(ASP015K,JNJ-54781532) Featured Peficitinib(ASP015K,JNJ-54781532) is a novel potent JAK inhibitor, which demonstrated potent efficacy in adjuvant-induced arthritis model in rats.
DC11734 PF-06263276 PF-06263276 (PF06263276, PF 6263276) is a potent, selective pan JAK inhibitor with IC50 of 2.2, 23.1, 59.9 and 29.7 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
DC10779 PF-06651600 Featured PF-06651600 is a potent JAK3-selective inhibitor with an IC50 of 33.1 nM.
DC12488 PF-06700841 tosylate Featured PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. PF-06700841 has been investigated for the treatment of psoriasis and lupus.
DC8741 Plerixafor octahydrochloride Featured Plerixafor octahydrochloride(AMD3100 8HCL) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.
DC11373 Polmacoxib Polmacoxib is an inhibitor of cyclooxygenase 2 (COX-2) and the carbonic anhydrase subtypes I (CAI) and CAII.
DC9742 Ponesimod Featured Ponesimod(ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM.
DC11914 Poseltinib Featured Poseltinib (HM-71224, LY-3337641) is a potent and selective, covalent inhibitor of Btk with IC50 of 1.95 nM.
DC9841 Fostamatinib(R788) Featured R788 (Fostamatinib), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.
DC1013 R788 disodium (Fostamatinib) Featured R935788 (Fostamatinib disodium, R788) is a Syk inhibitor with IC50 of 41 nM.
DC5146 RN486 Featured RN-486 is a Bruton's tyrosine kinase (Btk) inhibitor.
DC11671 RPL-554 RPL-554 (LS-193855, RPL554) is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively.
DC8436 Salmeterol Xinafoate Featured Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.
DC9410 SCH 527123 SCH-527123 is a potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively.
DC10193 Seletalisib Featured Seletalisib (UCB5857) is potent and selective PI3Kδ inhibitor with an IC50 of 12 nM.
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