| DC40169 |
DMG-PEG2000
Featured
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DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modific |
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| DC52020 |
ALC-0159
Featured
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ALC-0159 is a PEG/lipid conjugate (i.e. PEGylated lipid). Formulations containing ALC-0159 have been used in the development of lipid nanoparticles (LNPs) for the delivery of mRNA-based vaccines. |
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| DC58047 |
DSPE-PEG 2000
Featured
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PEG2000-DSPE is used for creating micelles that are able to carry drugs with low solubility. |
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| DC49193 |
PEG2000-C-DMG
Featured
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PEG(2000)-C-DMG represents a PEGylated derivative synthesized from 1,2-dimyristoyl-sn-glycerol (1,2-DMG). This compound is instrumental in the formulation of lipid nanoparticles (LNPs), particularly when combined with other lipidic compounds, for the efficient delivery of small interfering RNA (siRNA). Specifically, LNPs incorporating PEG(2000)-C-DMG and encapsulating siRNA designed to target the genes responsible for encoding programmed cell death protein ligand 1 (PD-L1) and PD-L2 have demonstrated efficacy in reducing the expression levels of PD-L1 and PD-L2 in monocyte-derived dendritic cells. Furthermore, formulations that include PEG(2000)-C-DMG are being actively explored in the advancement of LNPs aimed at the delivery of siRNA-based vaccines, highlighting its critical role in the development of therapeutic and prophylactic strategies. |
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| DC65713 |
mPEG-5000-DSPE, Na
Featured
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DSPE-MPEG(5000) is a PEGylated form of 1,2-distearoyl-rac-glycero-3-PE (DSPE). It has been used in the synthesis of lipid nanoparticles (LNPs) and liposomes for in vitro and in vivo two-photon bioimaging. |
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| DC65770 |
DMPE-mPEG2000(Na salt)
Featured
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| DC65786 |
mPEG2000-DSPE
Featured
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mPEG2000-DSPE is used in COVID 19 mRNA vaccines. It is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE . Formulations containing DSPE-MPEG(2000) have been used to prepare liposomes with long circulation time for the delivery of anticancer and antimalarial agents.. mPEG2000-DSPE has also been widely used as hydrophilic surface modifying agent for a variety types of hydrophobic nanoparticles, including recently reported lipid nanoparticle mRNA vaccines. |
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| DC60638 |
Acid-degradable PEG Lipid (ADP-2k)
Featured
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Acid-degradable PEG Lipid (ADP) composed of polyethylene glycol lipid is synthesized with the azido-acetal linker and used to generate RD-LNPs, which significantly improves the performance of LNP-mRNA complexes in vitro and in vivo. |
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| DC67111 |
18:1 PEG2000 PE
Featured
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18:1 PEG2000 PE (18:1 PEG-PE) is a polyethyleneglycol/phosphatidyl-ethanolamine conjugate. 18:1 PEG2000 PE can be used for drug delivery. |
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| DC67112 |
DPPE-PEG2000
Featured
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DPPE-PEG2000 (16:0 PEG2000 PE) is a PEG-modified lipids. 16:0 PEG2000 PE can reduce the nonspecific adsorption of protein and prolong circulation time in vivo. |
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| DC67161 |
MPEG-2000-DPPE Na
Featured
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DPPE-MPEG(2000) is a PEGylated form of 1,2-dipalmitoyl-rac-glycero-3-PE (DPPE). It has been used in the synthesis of anionic liposomes for drug redistribution and toxicity prevention. |
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| DC13590 |
Acid-degradable DSEP-PEG2000 |
Acid-degradable DSPE-PEG2000 composed of DSPE-PEG2000 is synthesized with the azido-acetal linker azido-acetal linker, which is stable at physiological pH (7.4) but rapidly hydrolyzes in the acidic environment of endosomes. This two-step mechanism (reduction followed by acid hydrolysis) ensures that ADP-LNPs remain stable during circulation but quickly release their payload upon entering target cells.It is designed by DC Chemicals |
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