Novel competitive MTH1 inhibitor

Novel tubulin inhibitor

Novel heterotrimeric G-protein Gi modulator, inhibiting GDP/GTP exchange on a Gαi subunit induced by a G-protein-coupled receptor agonist, but not on another G-protein from the Gαs family, regulating Gβγ-dependent cellular processes, most likely by causin

Novel inhibitor of TGF-β1 signaling pathway, inhibiting the upregulation of MAT2A mechanistically, dose-dependently activating PP2Cα and efficiently alleviating liver fibrosis

Novel potent activator of the natriuretic peptide receptor C (NPR-C) with EC 50 ~1 μM

Calcilytic negative allosteric modulator of calcium-sensing receptor (CaR)

Novel substrate for NAD(P)H: quinone oxidoreductase 1 (NQO1), acting as an effective intracellular ROS generator for the treatment of drug-resistant non-small-cell lung cancer

Novel NMDA/NR2B Antagonist

Novel activator of the Nrf2/HO-1 pathway, upregulating heme oxygenase-1 (HO-1) via promoting nuclear translocation of nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) to regulate LPS‐induced oxidative stress in macrophages

Nrf2-Activator is a potent Nrf-2 activator.

Novel inhibitor of CDK5 translocation, increasing CDK5 accumulation in the nucleus, suppressing both cancer cell proliferation and xenograft tumorigenesis.

Potent, non-selective partial agonist at GABAA receptors with little efficacy at the alpha1 subtype and more at alpha2 and alpha3

Novel Inhibitor with Activity against NS3/4A proteases from Multiple Hepatitis C Virus Genotypes

Novel allosteric inhibitor of HCV NS3 protein function

Novel molulator of SK-IK channels [small- and intermediate-conductance Ca2(+) -activated K(+) channels]

Novel potent α7 nAChR partial agonist

Novel α7 nAChR agonist at human and rat receptors

Novel potent growth inhibitor for gammaherpesvirus-associated B-lymphomas through activation of both the NF-κB and c-Myc-mediated signaling pathways

Novel Inhibitor of the Ras Converting Enzyme 1 (Rce1) Protease, Disrupting Ras Membrane Localization in Human Cells

Novel antagonist of the Grb7 SH2 domain; Antitumor Agent

Ras converting enzyme 1 (Rce1) inhibitor

Novel inhibitor of ABCG2 transporter function