Natural disrupter of DNA replication and transcription via DNA intercalation, reducing oxygen intake and carbohydrate metabolism and the excitability of muscle fibers, inhibiting the drug efflux pump P-glycoprotein

Novel antivirulence agent against Vibrio vulnificus, inhibiting the quorum-sensing signaling pathway by controlling the DNA-binding affinity of SmcR and thus effectively alleviating the virulence of V. vulnificus in vitro and in vivo

Novel microtubule destabilizer

Second-Generation GluN2C- and GluN2D-selective positive allosteric modulator (PAM) of the N-methyl-d-aspartate (NMDA) receptor

Novel Potent and Specific Ligand of r(CCUG)exp, Targeting r(CCUG) Repeats in Myotonic Dystrophy Type 2, Facilitating Degradation by RNA Quality Control Pathways

Novel scavenger receptor class B type I blocker

Novel inhibitor of HDL uptake induced by overexpression of scavenger receptor BI (SR-BI)

Novel Antiviral agent for Enterovirus D68

Efficient stabilizer of Mahoney procapsids

Potent and selective antagonist of 5-HT2A receptors

Novel inhibitor of PI3Kβ and PI3Kδ, inhibiting growth of PTEN deficient breast and prostate tumor

Prodrug of Racemetirosine, an inhibitor of tyrosine 3-monooxygenase

Novel potent DNA-alkylating agent, inhibiting TBP/DNA interaction

rac-NBI-74330 is a potent and selective CXCR3 antagonist.

Inhibitor of Janus kinases

Novel potent selective androgen receptor modulator (SARM)

Potent anti-free radical agent, elevating glutathione peroxidase (GSH-PX) and super oxide dismutase (SOD) levels and lowering malonaldehyde (MDA) level in vivo in the Alzheimer's model

Hsp90 N-terminal inhibitor

Novel inhibitor of the tyrosine kinase BCR-ABL and platelet-derived growth factor receptor, inhibiting mitosis entry in acute myeloid leukemia cells via suppression of Aurora kinase A expression

Novel potent inhibitor of p38 MAPK

Novel inhibitor of geranylgeranyl diphosphate synthase (GGDPS), showing significant reduction in tumor growth in mice

Novel inhibitor of geranylgeranyl diphosphate synthase (GGDPS)