Cat. No. | Product name | CAS No. |
DC22532 |
GNE-049
GNE-049 (GNE049) is a potent, selective, orally available inhibitor of CBP/p300 bromodomain with biochemical IC50 of 1.1/2.3 nM, respectively. |
1936421-41-8 |
DC23805 |
GNE-220
GNE-220 is a potent and selective inhibitor of MAP4K4 with IC50 of 7 nM, also inhibits MINK (MAP4K6), DMPK and KHS1 (MAP4K5) with IC50 of 9 nM, 476 nM and 1,110 nM. |
1199590-75-4 |
DC9934 |
GNE-272
GNE-272 is a in Vivo Probe for the Bromodomains of CBP/EP300. |
1936428-93-1 |
DC23337 |
GNE-2861
GNE-2861 is a potent, selective group II PAK (PAK4/5/6) inhibitor with IC50 of 7.5/126/36 nM, respectively, shows selectivity over group I PAKs (IC50=5.42/0.97/>10 uM for PAK1/2/3). |
1394121-05-1 |
DC21057 |
GNE-293
GNE-293 is a potent and selective PI3Kδ inhibitor with Ki of 0.47 nM, displays 256, 420, 219-fold selectivity over PI3Kα, PI3Kβ, PI3Kγ, respectively. |
1354955-67-1 |
DC11845 |
GNE-3500
GNE-3500 (GNE3500) is a potent, selective, and orally bioavailable RORγ inhibitor with IC50 of 47 nM in IL-17 promoter assays. |
1537859-24-7 |
DC12313 |
GNE-371
GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1(2). |
1926986-36-8 |
DC23374 |
GNE-375
GNE-375 is a potent, selective BRD9 inhibitor with IC50 of 5 nM, displays >480-fold selectivity over BRD4, CECR2, and TAF1. |
1926989-06-1 |
DC23869 |
GNE-431
GNE-431 is a potent, selective and noncovalent Btk inhibitor with IC50 of 3.2 nM and 2.5 nM for WT Btk and C481S mutant, respectively. |
1433820-83-7 |
DC8257 |
GNE 477
Featured
GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR. |
1032754-81-6 |
DC8502 |
GNE-490
Featured
GNE-490 is a highly selective pan-PI3K inhibitor and demonstrates selectivity over mTOR. |
1033739-92-2 |
DC7953 |
GNE-493
Featured
GNE-493 is a potent, selective, and orally available dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR respectively. |
1033735-94-2 |
DC11189 |
GNE-6468
GNE-6468 (GNE6468) is a potent and selective RORc inverse agonist (EC50=2 nM) with >1,000-fold selectivity for RORc over PPARγ. |
1677668-27-7 |
DC11555 |
GNE-6776
Featured
GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM . |
2009273-71-4 |
DC11729 |
GNE-781
Featured
GNE-781 is a potent, selective, non-CNS penetrant, orally active CBP/p300 bromodomain inhibitor with IC50 of 0.94/1.2 nM in TR-FRET assays. |
1936422-33-1 |
DC23165 |
GNE-7915 tosylate
GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM. |
2070015-00-6 |
DC26024 |
GNE-8324
Featured
GNE-8324 is a potent and selective NMDA receptor PAM. |
1698901-76-6 |
DC23350 |
GNE-886
GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM. |
2101957-05-3 |
DC11732 |
GNE-900
GNE-900 (GNE900) is a potent, selective, ATP-competitive, and orally bioavailable Chk1 inhibitor with IC50 of <1 nM. |
1200126-26-6 |
DC20074 |
GNE-955
GNE-955 is a potent pan Pim kinase inhibitor with Kis of 18, 110, 8 nM for Pim1, Pim2, Pim3, respectively. |
1527523-39-2 |
DC20204 |
GNF-6231
GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM. |
1243245-18-2 |
DC9285 |
GNF-7
Featured
GNF-7 is a potent type-II kinase Bcr-Abl inhibitor with IC50 of <5 nM, 61 nM, 122 nM, 136 nM, and 133 nM for M351T, T315I, E255 V, G250E, and c-Abl, respectively. |
839706-07-9 |