Cat. No. | Product name | CAS No. |
DC21071 |
GS-9451
GS-9451 (Vedroprevir) is a potent HCV NS3/4A protease inhibitor with Ki of 0.41 nM, inhibits HCV GT-1b NS3/4A with IC50 of 3.2 nM in enzymatic assays. |
1098189-15-1 |
DC23244 |
GS-9695
GS-9695 is a potent, non-catalytic site HIV integrase inhibitor with wild type EC50 of 1.2 nM.. |
1471256-08-2 |
DC11297 |
GS-9822
GS-9822 is a novel, potent NCINI with a higher barrier to resistance relative to early prototype NCINIs, including GS-9695. |
2219362-41-9 |
DC23876 |
GSA-10
Featured
GSA-10 is a novel small-molecule positive modulator of Smoothened with EC50 of 1.2 uM in the differentiation assay. |
300833-95-8 |
DC9515 |
PI3K inhibitor GS1059615
GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively. |
958852-01-2 |
DC7422 |
GSK1292263
Featured
GSK1292263 is a novel GPR119 receptor agonist used for the treatment of type 2 diabetes. |
1032823-75-8 |
DC2069 |
IGF-1R inhibitor GS1904529A
GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, respectively. |
1089283-49-7 |
DC9943 |
PI3Kδ inhibitor GS2269557
GSK-2269557 is a potent and selective PI3Kδ inhibitor over the closely related isoforms. |
1254036-71-9 |
DC9944 |
PI3Kδ inhibitor GS2292767
GSK2292767 is a potent and selective PI3Kδ inhibitor. |
1254036-66-2 |
DC9712 |
Iinerixibat
GSK2330672 is a highly potent, nonabsorbable ASBT(apical sodium-dependent bile acid transporter) inhibitor (hASBT IC50=42 ± 3 nM) . |
1345982-69-5 |
DC7650 |
GSK2334470
Featured
GSK2334470 is a novel PDK1 inhibitor with IC50 of ~10 nM, with no activity at other close related AGC-kinases. |
1227911-45-6 |
DC8520 |
GSK-25
Featured
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested). |
874119-56-9 |
DC9719 |
Lp-PLA2 -IN-1(GSK2814338)
Featured
GSK2814338, also known as Lp-PLA2 -IN-1, is a Lp-PLA2 inhibitor |
1420367-28-7 |
DC9721 |
GSK2983559 active metabolite
Featured
GSK2983559 active metabolite is an active metabolite of GSK2983559. GSK2983559 active metabolite is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1. |
1423186-80-4 |
DC9717 |
amyloid P-IN-1(GSK3039294)
Featured
GSK3039294 is a Serum amyloid P component inhibitor. |
1819986-22-5 |
DC10391 |
EBI2 inhibitor GS682753A
GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM. |
1334294-76-6 |
DC2070 |
GSK690693
Featured
GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively. |
937174-76-0 |
DC26130 |
GSK8612
Featured
GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1. |
2361659-62-1 |
DC10061 |
PI4KA inhibitor-A1
Featured
GSK-A1 is a potent inhibitor of PI4KA. In vitro using HEK-AT1 cells, GSK-A1 had an IC50 of about 3 nM. |
1416334-69-4 |
DC10064 |
GSK-F1
Featured
GSK-F1 is a potent inhibitor of PI4KA. |
1402345-92-9 |
DC7858 |
GSK-J1
Featured
GSK-J1 is a potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM for human JMJD3 in vitro). |
1373422-53-7 |
DC23890 |
GSM-1
GSM-1 (GSM1) is a γ-secretase modulator that directly targets the transmembrane domain (TMD) 1 of presenilin 1, shows potent Aβ42-lowering effect (IC50=0.348 uM) in a cell-based assay. |
884600-68-4 |