Cat. No. | Product name | CAS No. |
DC9162 |
Ranolazine HCl
Featured
Ranolazine(RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP). |
95635-56-6 |
DC1048 |
Rapamycin (Sirolimus)
Featured
Rapamycin (Sirolimus, AY-22989, WY-090217) is a specific mTOR inhibitor with IC50 of ~0.1 nM. - |
53123-88-9 |
DC8185 |
Verosudil(AR-12286)
Rho-kinase (ROCK) inhibitor |
1414854-42-4 |
DC10583 |
RO 5028442
Featured
RO5028442 is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a). |
920022-47-5 |
DC8198 |
RTA-408(Omaveloxolone)
Featured
RTA-408 is a synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 and inhibits the proinflammatory transcription factor NF-κB. |
1474034-05-3 |
DC8224 |
Lifitegrast(SAR 1118)
Featured
SAR 1118 is a potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonist for treating dry eye. |
1025967-78-5 |
DC10925 |
SAR-100842
SAR-100842 (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays. |
1195941-38-8 |
DC9600 |
Senicapoc
Featured
Senicapoc(ICA17043) is a potent and selective Gardos channel blocker; blocked Ca(2+)-induced rubidium flux from human RBCs/ inhibited RBC dehydration with IC50s of 11 nM/30 nM, respectively. IC50 value: 11/30 nM [1] Target: Gardos channel in vitro: I |
289656-45-7 |
DCAPI1485 |
Silodosin
Featured
Silodosin(Rapaflo) is an α1-adrenoceptor antagonist with high uroselectivity. Silodosin causes practically no orthostatic hypotension (in contrast to other α1 blockers). Since Silodosin is a highly selective inhibitor of the α1A adrenergic receptor, it ca |
160970-54-7 |
DC8592 |
Sivelestat (sodium salt hydrate)
Featured
Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse. |
201677-61-4 |
DC8500 |
SKQ1(Visomitin)
Featured
SKQ1 prevents amyloid-beta-induced impairment of long-term potentiation in rat hippocampal slices. |
934826-68-3 |
DC9732 |
Sufugolix(TAK-013)
Featured
Sufugolix(TAK-013) is a non-peptide, orally-active, selective antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (IC50 = 0.1 and 0.06 nM for affinity and in vitro inhibition, respectively). |
308831-61-0 |
DC7306 |
TAK-438
Featured
TAK-438 is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. |
1260141-27-2 |
DC10390 |
TD139
Featured
TD139 is a novel high-affinity inhibitor of the galectin-3 carbohydrate binding domain with a Kd of 14 nM. |
1450824-22-2 |
DC11026 |
Tecovirimat
Featured
Tecovirimat (ST-246, Tpoxx) is a potent, orally bioavailable, first-in-class inhibitor of orthopoxvirus egress with EC50 of 0.01-0.6 uM against a panel of Orthopoxviruses; ST-246 is active against multiple orthopoxviruses, including vaccinia, monkeypox, c |
869572-92-9 |
DC9148 |
Tolvaptan
Featured
Tolvaptan is a selective, competitive arginine vasopressin receptor 2 antagonist with an IC50 of 1.28μM for the inhibition of AVP-induced platelet aggregation. |
150683-30-0 |
DC11385 |
Trofinetide(NNZ2566)
Featured
Trofinetide (NNZ-2566) is an analog of a molecule which is derived from IGF-1 and occurs naturally in the brain. IGF-1 is a growth factor stimulated by growth hormone. |
853400-76-7 |
DC10737 |
Tropifexor (LJN452)
Featured
Tropifexor (LJN452) is a highly potent non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH). |
1383816-29-2 |
DC10083 |
UK-371804
Featured
UK-371804 is a potent and selective uPA inhibitor with excellent enzyme potency (Ki 10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). |
256477-09-5 |
DC10339 |
Vadadustat
Featured
Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia. |
1000025-07-9 |
DC9816 |
Valbenazine(NBI-98854)
Featured
Valbenazine(NBI-98854) is a potent and selective VMAT2 inhibitor.. |
1025504-45-3 |
DC1059 |
Lumacaftor(vx-809,vx809)
Featured
VX-809 is a CFTR modulator with EC50 of 0.1 μM. |
936727-05-8 |