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| Cas No.: | 201677-61-4 |
| Chemical Name: | Sivelestat Sodium hydrate |
| Synonyms: | LY 544349,ONO-5046,LY-544349,LY544349 |
| SMILES: | O.O.O.O.[Na+].O=C(CNC(C1=CC=CC=C1NS(C1=CC=C(OC(C(C)(C)C)=O)C=C1)(=O)=O)=O)[O-] |
| Formula: | C20H29N2NaO11S |
| M.Wt: | 528.5 |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.ONO-5046 did not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 microM. In in vivo studies, ONO-5046 suppressed lung hemorrhage in hamster (ID50 = 82 micrograms/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase [1]. Sivelestat sodium hydrate is an anti-neutrophil elastase inhibitor and may be one of the treatment options for acute respiratory failure due to pneumocystis pneumonia in AIDS patients [2]. |
MSDS
COA
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| 2018-0101 |
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| 2018-0101 |
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