| DC10583 |
RO 5028442
Featured
|
RO5028442 is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a). |
|
| DC8198 |
RTA-408(Omaveloxolone)
Featured
|
RTA-408 is a synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 and inhibits the proinflammatory transcription factor NF-κB. |
|
| DC8224 |
Lifitegrast(SAR 1118)
Featured
|
SAR 1118 is a potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonist for treating dry eye. |
|
| DC10925 |
SAR-100842
Featured
|
SAR-100842 (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays. |
|
| DC9600 |
Senicapoc
Featured
|
Senicapoc(ICA17043) is a potent and selective Gardos channel blocker; blocked Ca(2+)-induced rubidium flux from human RBCs/ inhibited RBC dehydration with IC50s of 11 nM/30 nM, respectively.
IC50 value: 11/30 nM [1]
Target: Gardos channel
in vitro: I |
|
| DCAPI1485 |
Silodosin
Featured
|
Silodosin(Rapaflo) is an α1-adrenoceptor antagonist with high uroselectivity. Silodosin causes practically no orthostatic hypotension (in contrast to other α1 blockers). Since Silodosin is a highly selective inhibitor of the α1A adrenergic receptor, it ca |
|
| DC8592 |
Sivelestat (sodium salt hydrate)
Featured
|
Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse. |
|
| DC8500 |
SKQ1(Visomitin)
Featured
|
SKQ1 prevents amyloid-beta-induced impairment of long-term potentiation in rat hippocampal slices. |
|
| DC9732 |
Sufugolix(TAK-013)
Featured
|
Sufugolix(TAK-013) is a non-peptide, orally-active, selective antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (IC50 = 0.1 and 0.06 nM for affinity and in vitro inhibition, respectively). |
|
| DC7306 |
TAK-438
Featured
|
TAK-438 is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. |
|
| DC10390 |
TD139
Featured
|
TD139 is a novel high-affinity inhibitor of the galectin-3 carbohydrate binding domain with a Kd of 14 nM. |
|
| DC11026 |
Tecovirimat
Featured
|
Tecovirimat (ST-246, Tpoxx) is a potent, orally bioavailable, first-in-class inhibitor of orthopoxvirus egress with EC50 of 0.01-0.6 uM against a panel of Orthopoxviruses; ST-246 is active against multiple orthopoxviruses, including vaccinia, monkeypox, c |
|
| DC9148 |
Tolvaptan
Featured
|
Tolvaptan is a selective, competitive arginine vasopressin receptor 2 antagonist with an IC50 of 1.28μM for the inhibition of AVP-induced platelet aggregation. |
|
| DC11385 |
Trofinetide(NNZ2566)
Featured
|
Trofinetide (NNZ-2566) is an analog of a molecule which is derived from IGF-1 and occurs naturally in the brain. IGF-1 is a growth factor stimulated by growth hormone. |
|
| DC10737 |
Tropifexor (LJN452)
Featured
|
Tropifexor (LJN452) is a highly potent non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH). |
|
| DC10083 |
UK-371804
Featured
|
UK-371804 is a potent and selective uPA inhibitor with excellent enzyme potency (Ki 10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). |
|
| DC10339 |
Vadadustat
Featured
|
Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia. |
|
| DC9816 |
Valbenazine（NBI-98854）
Featured
|
Valbenazine(NBI-98854) is a potent and selective VMAT2 inhibitor.. |
|
| DC1059 |
Lumacaftor(vx-809，vx809)
Featured
|
VX-809 is a CFTR modulator with EC50 of 0.1 μM. |
|
| DC9187 |
Mosapride Citrate |
Mosapride citrate is a gastroprokinetic agent that acts as a selective 5HT4 agonist. |
|
| DC9873 |
Selonsertib（GS-4997）
Featured
|
Selonsertib（GS-4997）is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. |
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