(±)-Blebbistatin is a cell cycle inhibitor and a selective inhibitor of non-muscle myosin II.

5-CFDA is a cell membranes permeatable non-fluorescent prodrug of 5-carboxyfluorescein. It shows strongly fluorescent to differentiate viable cells from apoptotic cells after being enzymatically hydrolyzed inside cells.

6-CFDA is a cell membranes permeatable non-fluorescent prodrug of 5-carboxyfluorescein. It shows strongly fluorescent to differentiate viable cells from apoptotic cells after being enzymatically hydrolyzed inside cells.

Epigenetic Multiple Ligand is a cell-permeable inhibitor of substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1. It acts by inducing either apoptosis or granulocytic differentiation.

BAY32-5915 is an IKKalpha inhibitor.

Cilostamide is a selective inhibitor of type III phosphodiesterase (PDE3).

Clofilium Tosylate is a K+ channel blocker, cardiac depressant, and anti-arrhythmic agent.

Ranitidine-N-oxide is a metabolite of Ranitidine. Ranitidine is a histamine H2-receptor antagonist, inhibiting the normal and meal-stimulated secretion of stomach acid. Ranitidine, sold under the trade name Zantac among others, is a medication which decreases stomach acid production.

Iprovalicarb is a fungicide specific to oomycetes.

NVS-CECR2-1 is a potent and selective CECR2 inhibitor.

UK-78282 HCl is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels.

Dofequidar fumarate is a potent inhibitor of MDR-1.

Fendiline HCl is a potent acid sphingomyelinase (ASM) inhibitor, reducing the phosphatidylserine (PtdSer) and cholesterol content of the inner plasma membrane and inhibiting calcium function in muscle cells in excitation-contraction coupling.

HDAC8-IN-2 is a selective HDAC8 inhibitor.

Aloenin is a moderate inhibitor of BACE.

PF-06424439 is a potent and selective Diacylglycerol Acyltransferase 2 ( DGAT2) inhibitor with DGAT2 IC50 ± SEM (nM) (human/rat/dog) 14 ± 1/38 ± 4/16 ± 1. PF-06424439 demonstrated excellent ADMET properties and decreased circulating and hepatic lipids when orally administered to dyslipidemic rodent models. PF-06424439 inhibited DGAT2 of different species (human, rat, and dog) with similar potency. Among related acyltransferases, no significant inhibition was observed for PF-06424439 (up to 50 μM) against human MGAT2 or MGAT3, DGAT1, or mouse MGAT1, indicating a high selectivity (>2000-fold) against these enzymes.

Gardiquimod is a TLR7 agonist, inducing the activation of NF-B in HEK293 cells expressing human or mouse TLR7.

TP2 is an inhibitor of polyketide synthase 13 (Pks13), preventing synthesis of mycolic acid and resulting in mycobacterial cell death.

Neurodazine is a neurogenic inducer for converting pluripotent P19 cells into electrophysiologically active neurons.

Nalmefene HCl is an antagonist of the opioid receptors.

EPPS is a rescuer of A? aggregation and behavioural deficits, binding to A? aggregates and converting them into monomers.

ADP Sodium is an adenine nucleotide, converting into ATP by ATP synthases, affecting platelet activation through its interaction with P2Y1, P2Y12 and P2X1.

C8 Ceramide is a cell-permeable analog of naturally occurring ceramides.

IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.

PF-5274857 HCl is a potent and selective smoothened (Smo) receptor antagonist.

Milbemycin A3 Oxime is an opener of glutamate sensitive chloride channels in neurons of invertebrates, leading to paralysis by hyperpolarisation of these cells and blocking signal transfer. Milbemycin A3 Oxime is also an anthelmintic. Formulations containing milbemycin A3 oxime, in combination with milbemycin A4 oxime, have been used in the treatment of parasitic infections in dogs.

SKI-II HCl is a substrate competitive, reversible, and highly specific inhibitor of sphingosine kinase.

ACT-678689 is a potent inhibitor of tryptophan hydroxylase 1 (TPH1).

Toltrazuril (Tol) is a broad-spectrum anticoccidiosis drug that is widely used in the prevention and treatment of coccidiosis infection in poultry and mammals.

FAD-Na2 is a redox cofactor (electron carrier) by flavoproteins including succinate dehydrogenase (complex), α-ketoglutarate dehydrogenase, apoptosis-inducing factor 2 (AIF-M2, AMID), folate/FAD-dependent tRNA methyltransferases, and N-hydroxylating flavoprotein monooxygenases.

BLI-489 Hydrate is a novel beta-lactamase inhibitor.

Enbucrilate is a tissue adhesive, forming polymer films at oil-water interfaces and revealing films of diverse morphology.

GA3-AM is a cell permeable chemical dimerizer.

LAP is a photocrosslinker for hydrogels.

TMRM is a sensitive fluorescent probe for mitochondrial membrane potential.

FHZ is a highly selective, cell-permeable, non-cytotoxic probe for dual channel detection of (OH radical) and HOCl in live cells and zebrafish embryos.

AalphaC is a potential human carcinogen.

MS0015203 is a potent and selective agonist of the neuropeptide receptor GPR171.

Imidafenacin HCl is a potent antimuscarinic agent, exhibiting selectivity toward muscarinic M3 receptors.

ABC44 is a potent and selective inhibitor of palmitoyl-protein thioesterase 1 (PPT-1).

NSC-57969 is a MDR-selective agent, exhibiting a robust Pgp-dependent toxic activity across diverse cancer cell lines.

Cerebrosterol is a major brain metabolite of cholesterol.

MitoNeoD is a novel mitochondria-targeted O2(??) probe that can be used in vivo. It prevents DNA intercalation. MitoNeoD incorporates a carbon-deuterium bond, and enhances O2(??) selectivity. MitoNeoD comprises a O2?--sensitive reduced phenanthridinium moiety modified to prevent DNA intercalation, as well as a carbon-deuterium bond to enhance its selectivity for O2?- over non-specific oxidation, and a triphenylphosphonium lipophilic cation moiety leading to the rapid accumulation within mitochondria. MitoNeoD is a versatile and robust probe to assess changes in mitochondrial O2?- from isolated mitochondria to animal models, thus offering a way to examine the many roles of mitochondrial O2?- production in health and disease.

Dihydroresveratrol is an SIRT1 activator. It is a primary metabolite of resveratrol.

ATC0065 dihydrochloride is a novel nonpeptidic and potent melanin-concentrating hormone receptor 1 (MCHR1) selective antagonist.

ATC0175 is a novel nonpeptidic and orally active melanin-concentrating hormone receptor 1 (MCHR1) antagonist.

Delphinidin Chloride is an inhibitor of BDNF-induced migration and invasion in SKOV3 ovarian cancer cells.

Ac4ManNAz is a novel probe for metabolic labeling of sialoglycans, selectively imaging polysialic acids in neurons.

DBC is a ubiquitous environmental pollutant, inducing significant DNA strand break levels and micronuclei in HepG2 cells.

DOCK5-IN-C21 is an allosteric inhibitor of the guanine nucleotide exchange factor DOCK5.

SRI-29574 is an allosteric dopamine transporter ligand.

Halofuginone Hydrobromide is a potent prolyl-tRNA synthetase inhibitor.

NPD8716 is a hepatitis B/D virus entry inhibitor, targeting sodium taurocholate cotransporting polypeptide (NTCP).

Myxothiazol is an inhibitor of mitochondrial respiratory chain complexes III. Myxothiazol induces transcription of the p53-responsive SESN2 gene that plays an important role in stress response and homeostatic regulation.

Piericidin A is an irreversible inhibitor of mitochondrial complex I that strongly associates with ubiquinone binding sites in both mitochondrial and bacterial forms of the enzyme. Piericidin A induces transcription of the p53-responsive SESN2 gene which plays an important role in the stress response and homeostatic regulation.

NAGKi is an inhibitor of N-acetylglucosamine kinase (NAGK) and N-acetylmannosamine kinase (NAMK).

Lumiflavine is a riboflavin uptake inhibitor. Lumiflavine is produced by the photolysis of vitamin B2 (Riboflavin).

PU-H71 hydrate is a potent inhibitor of heat shock protein 90 (Hsp90).

Bromfenac Sodium Sesquihydrate is a nonsteroidal anti-inflammatory drug (NSAID), which inhibits cyclooxygenase II (COX-2).

CDK4-IN-1 is a selective inhibitor of cyclin-dependent kinase 4.

BAPTA Tetrasodium is a selective fluorescent chelator for calcium.

Metominostrobin is a broad-spectrum fungicide.

Nicotinamide Riboside is a precursor of NAD+ and a source of vitamin B3 (niacin). Nicotinamide Riboside increases intracellular and mitochondrial NAD+ content in C2C12.

Mafenide Hydrochloride is an antibiotic against many gram-positive and gram-negative organisms, including Pseudomonas aeruginosa.

Amthamine dihydrobromide is a histamine H2 agonist.

MNF, also known as 3,4-MNF, is an antagonist of the aryl hydrocarbon receptor (AhR). MNF reduces UVR-mediated immunosuppression and induces Tregs in murine contact hypersensitivity (CHS).

HBX is a deubiquitinase inhibitor. It inhibits HAdV type 5 (species C, HAdV-C5) replication and oncogenic transformation through inhibition of the cellular pro-viral factor ubiquitin-specific protease 7 (USP7). HBX also significantly inhibits virus genome replication and progeny release of all adenovirus types tested, with the exception of types 12 and 31, from tested species.

CyPPA is a positive modulator of SK3 and SK2, which reduces the activity of dopaminergic neurons. CyPPA inhibits dopamine release, and counteracts hyperdopaminergic behaviors induced by methylphenidate.

IR-780 iodide is a near‐infrared fluorescent (NIF) dye for the exclusive characterization of human CSCs through the HIF‐1α/glycolysis dependent mitochondrial transporter ABCB10's activity.

SGC-GAK-1N is a negative control for SGC-GAK-1.

Fluoroglutamine (2S,4R) is a Glutamine analog, not metabolized in the TCA cycle, but it can be incorporated into proteins and peptides. Fluoroglutamine (2S,4R) can be used as assess transporter (ASCT2) activity or protein synthesis rate.

JAK3 Inhibitor VI is a cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3).

Flobetapir is a blood-brain barrier crossing ligand of amyloid protein deposits in the brain.

20-HETE is a lipid mediator which activates the transcription of ACE via NFkB translocation and promoter binding. This causes detrimental effects in cerebral circulation, and modulating KCa3.1 channels.

SB-747651A dihydrochloride is a potent MSK1 inhibitor; also inhibiting other AGC group kinases.

TD-3 is an inhibitor of the salt-bridge formation between β-Asp94 and β-His146 hemoglobin (Hb), binding to Hb β-Cys93.

24-Methylenecholesterol is a natural marine sterol, which stimulates cholesterol acyl transferase (ACAT) in human macrophages.

VI-16832 is a broad spectrum type-I kinase inhibitor.

DFHBI is a mimic of green fluorescent protein (GFP) fluorophore for imaging RNA in living cells.

Cafestol is a natural bioactive substance in coffee, having antidiabetic properties in KKAy mice. Cafestol has been shown to exercise anti-angiogenic and anti-tumorigenic effects.

Rucaparib camsylate is a potent, orally available inhibitor of poly ADP-ribose polymerase (PARP) 1 and 2.

DCPP is a potent inhibitor of DHCR7, which is known as the last enzyme in cholesterol biosynthesis.

Nagilactone B is a unique selective LXR regulator which suppresses atherosclerosis in apoE-deficient mice via promotion of cholesterol efflux in macrophages.

Ascorbate, also known as Ascorbicin, is a DNase I inhibitor. Ascorbate is an antioxidant which functions as a reducing agent and coenzyme in several metabolic pathways.

Pregnenolone-carbonitrile is an agonist of the rodent pregnane X receptor (PXR), inducing cytochrome P450.

MitoEbselen-2, also known as MitoPeroxidase-2, is a radiation mitigator which reduces lipid hydroperoxides and prevents apoptotic cell death. When administered 24 hours postirradiation, MitoEbselen-2 was shown to increase the survival of mice exposed to whole body γ-irradiation.

MMG-11 is a potent and selective dual inhibitor of TLR2/1 and TLR2/6 signaling with low cytotoxicity.

Micheliolide is a natural, irreversible activator of pyruvate kinase M2, and a suppressor of leukemia cells.

Benzomalvin A is a filamentous fungal secondary metabolite.

RF9 is a potent and selective neuropeptide FF receptor antagonist, targeting both NPFF1 and NPFF2 receptors.

Orbifloxacin is an antibiotic which is effective against most Gram-negative bacteria, including Enterobacteriaceae and Pseudomonas.

Pizotifen is a serotonin antagonist which acts mainly at the 5-HT1, 5-HT2A, and 5HT2C receptors with some antihistamine activity.

MT63-78 is a direct activator of AMPK, and an inhibitor of prostate cancer growth by blocking lipogenesis.

Cyclopiazonic Acid is a natural mycotoxin which inhibits the sarcoplasmic reticulum Ca2+ pump.

Ornithine-α-ketoglutarate is a modulator of the respiratory burst via nitric oxide and polyamine generation, thereby improving immune status during stress.

AG-17724 is a potent peptidyl-prolyl isomerase (PPIase) Pin1 inhibitor.

Terpendole E is an atypical L5 site inhibitor.

Echimidine is one of the natural predominant pyrrolizidine alkaloids (PAs) found in honeys produced in Australia and New Zealand. Echimidine activates PXR and induces PXR-mediated CYP3A4 expression.

Ro-31-7549 Monohydrate is a cell permeable, reversible, selective protein kinase C (PKC) inhibitor.

Norfluoxetine hydrochloride is an active metabolite of fluoxetine.

Asperulosidic Acid is a natural glycoside which inhibits both AP-1 transactivation, and cell transformation, in the mouse epidermal JB6 cell line.

Deacetylasperulosidic Acid is a natural glycoside which demonstrates antioxidant activity in vivo and in human trials.

Loline is a natural insecticidal and deterrent to a broad range of insects, including species in the Hemiptera, Coleoptera, Hymenoptera, Lepidoptera, and Blattodea orders. Loline deters species such as the bird cherry-oat aphid (genus Rhopalosiphum), large milkweed bug (Oncopeltus fasciatus), and American cockroach (Periplaneta americana), thereby protecting the host plant from insect herbivory.

Momordicine I is a secondary metabolite from bitter melon (Momordica charantia L.) which significantly inhibits Spodoptera litura ovary cell line (SL-1 cell) proliferation.

Grifolic acid is a natural inhibitor of the alpha-linolenic acid (LA)-induced ERK and [Ca(2+)](i) responses in GPR120-expressing cells, and a promotor of ERK and [Ca(2+)](i) responses in GPR120-expressing cells.

Adenanthin is a natural inhibitor of thiol-dependent antioxidant enzymes, impairing the effector functions of human natural killer cells.

Nothofagin is a natural anti-oxidant which inhibits endothelial protein C receptor (EPCR) shedding. Nothofagin shows diuretic, natriuretic, and potassium-sparing effects associated with prostanoids generation and muscarinic receptor activation.

Nimbolide is a natural inhibitor of pancreatic cancer growth and metastasis through ROS-mediated apoptosis. It inhibits epithelial-to-mesenchymal transition.

CY5 is a photoswitchable fluorescent labeling reagent.

FN-439 is a matrix metalloproteinase inhibitor which targets MMP-1 and MMP-9.

MMP9-IN-I is a cell-permeable, potent, and reversible MMP-9 inhibitor.

360A is a stabilizing G-Quadruplex ligand which has potent selectivity toward G-quadruplex structures of the telomeric 3'-overhang.

3F8 is a selective and potent GSK-3? inhibitor.

Fluvastatin Methyl Ester is a precursor for Fluvastatin, which is a blocker of the liver enzyme HMG-CoA reductase.

p-Tolylmaleimide is a water channel inhibitor which binds to aquaporin Z (AqpZ).

Quinaprilat is an angiotensin converting enzyme inhibitor.

Tebufenpyrad is an acaricide and insecticide widely used in greenhouses. It is commonly used to control populations of mites and ticks.

dtBHQ is a non-arylating oxidizable phenol as the source of reactive oxygen species (ROS).

Bisindolylmaleimide VII is a selective inhibitor of protein kinase C.

NHNB is a selective inhibitor of histone deacetylases-8 (HDAC8). NHNB provides the most potent CE4 inhibitor reported to date.

Hemicholinium-3 is a competitive antagonist of CHT-mediated choline transport.

WR-1065 Dihydrochloride is a metabolite of Amifostine.

Galnon is a selective, non-peptide agonist at the galanin receptors GALR.

L48H37 is a specific myeloid differentiation 2 (MD2) inhibitor.

LP-935509 is a potent inhibitor of the Adapter protein-2 Associated Kinase 1 (AAK1).

Carboprost tromethamine is a Prostaglandin F2α analog.

PSEM308 HCl is an agonist of pharmacologically selective actuator module (PSAM) which activates PSAML141F-GlyR chimeric ion channels.

TL12-186 is a multikinase degrading PROTAC.

TL13-27 is a negative control for TL12-186.

Glasdegib Maleate is a potent and orally bioavailable inhibitor of smoothened.

UK-59811 HCl is a calcium channel blocker which inhibits CaVAb and binds at the outer, lipid-facing surface of the pore at the interface between two CaVAb subunits.

TFIIH Modulator-12 is a small molecule destabilization inducer of the trichothiodystrophy group A protein (TTD-A or p8) dimerization which modulates TFIIH transcriptional activity.

TFIIH Modulator-19 is a small molecule destabilization inducer of the trichothiodystrophy group A protein (TTD-A or p8) dimerization which modulates TFIIH transcriptional activity.

Tuftsin is a self-immunomodulatory molecule produced by the spleen by enzymatic cleavage of a leukophilic gamma-globulin which stimulates the phagocytic activity of blood polymorphonuclear leukocytes and neutrophils in particular. The peptide is located in the Fd fragment of the gamma-globulin molecule.

Monosulfuron is an herbicide.

S1QEL is a suppressor of mitochondrial respiratory complex I site IQ electron leak which suppresses superoxide and/or H2O2 production without altering oxidative phosphorylation.

Manumycin A is a Farnesyltransferase inhibitor which suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells, inhibiting IKKβ activity through covalent cross-linking of IKKβ monomers via C179.

L-4FPG is an inhibitor of the neutral amino acid transporters ASCT1 and ASCT2. L-4FPG shows good brain penetration and potently reduces amphetamine-induced hyperlocomotion.

GO-Y078 is an antiangiogenic curcumin analog which inhibits actin stress fiber formation, thereby resulting in mobility inhibition.

gp130-agonist-2 is a brain penetrant gp130 agonist which protects against NMDA-induced toxicity and increases STAT3 phosphorylation.

ADPS is a water-soluble modified trinder reagent.

Englerin A is a natural potent activator of ion channels formed by Transient Receptor Potential Canonical 4 and 5 proteins (TRPC4 and TRPC5).

AG-538 is a PI5P4Kα inhibitor which targets the ATP site.

SHIN1 is a potent dual inhibitor of human serine hydroxymethyltransferase 1/2 (SHMT1/2).

AGN-192403 hydrochloride is an I1 imidazoline binding site selective ligand with a potency at I1 comparable to moxonidine, but devoid of affinity for adrenoceptors and the I2 binding site.

FlAsH-EDT2 is a pro-fluorescent, membrane-permeable, covalent CCPGCC targeted probe.

CS1 is a potent inhibitor of microtubule polymerization via interaction with the colchicine-binding pocket of tubulin, inducing unique histone phosphorylation patterns distinct from those induced by colchicine. CS1 is an antimitotic.

SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. SNJ-1945 protects SH-SY5Y cells against MPP(+) and rotenone. SNJ-1945 reduces murine retinal cell death in vitro and in vivo. SNJ-1945 has good aqueous solubility, can prevents the heart from KCl arrest-reperfusion injury associated with the impairment of total Ca(2+) handling by inhibiting the proteolysis of alpha-fodrin as a cardioplegia.

MJ-15 is a potent and selective antagonist of cannabinoid CB1 receptor.

ADX10059 Hydrochloride is a metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.

QLT0267 is an ATP-competitive selective inhibitor of integrin-linked kinase (ILK).

PRL-3 Inhibitor I is a potent PRL-3 inhibitor with an IC50 of 0.9 μM. PRL-3 Inhibitor I shows a reduced invasion in cell-based assay.

EW-7197 Hydrochloride is a highly potent, selective, and orally bioavailable inhibitor of TGF-β type 1 receptor kinase.

NASTRp is an inhibitor of CREB-CBP complex which possesses anti-cancer effects along with cell cycle regulation, autophagy suppression, and endoplasmic reticulum stress.

Vicriviroc Malate is a potent, highly selective, and orally bioavailable CCR5 antagonist.

TLR7/8 agonist-5d is a TLR7/8 agonist which shows prominent immunostimulatory activities.

FK409 is a cell permeable NO donor which produces vasorelaxation.

GSK2795039 is the first small molecule NADPH oxidase 2 (NOX2) inhibitor.

Oxathiapiprolin is a oomycete fungicide, targeting an oxysterol binding protein.

Fluxapyroxad is a broad-spectrum fungicide which inhibits the succinate dehydrogenase (SQR) enzyme.

Saridegib HCl, also known as IPI-926 HCl, is a hedgehog pathway inhibitor which inhibits smoothened.

aPKC-I is an inhibitor of atypical protein kinase C (aPKC ) which inhibits both PKCζ and PKCι with high specificity and prevents VEGF-induced endothelial permeability in cell culture and in vivo, thereby blocking ischemia-reperfusion (IR)-induced permeability.

Ascofuranone is an inhibitor of the ubiquinol oxidase activity of Trypanosoma brucei mitochondrial alternative oxidase (TAO), as well as an inhibitor of HsDHODH.

STAT3-IN-8 is a cell permeable JAK1/JAK2/TYK2/STAT3 activation inhibitor.

R-IMPP Hydrochloride is an anti-secretagogue of PCSK9, promoting uptake of LDL-C in hepatoma cells by increasing LDL-R levels and blocking PCSK9 translation.

Tetrazanbigen is an inducer of S phase arrest and apoptosis in hepatocellular carcinoma QGY-7701.

BC-11 hydrobromide is an inhibitor of Urokinase-Plasminogen Activator (uPa) which induces additional impairment of mitochondrial activity, the production of reactive oxygen species, and promotion of apoptosis.

Betaine Aldehyde Chloride is an inhibitor of anaerobic choline metabolism by human gut bacteria.

TR-IN-1-850 is a selective blocker of T3 binding to both TRα and TRβ.

Ac-Phe-NH2 is a non-competitive inhibitor (Ki = 8 ± 1.2 mM) of polyubiquitin chain elongation by destabilizing the active trimer.

Clothianidin is an insecticide which acts as an agonist of acetylcholine, thereby stimulating nAChR and activating post-synaptic acetylcholine receptors but not inhibiting AChE.

Epiberberine Chloride is a natural anticancer agent which stabilizes telomeric G4s and inhibits telomerase, specifically recognizing the hybrid-2 telomeric G4 predominant in physiologically relevant K+ solution and converts other telomeric G4 forms to hybrid-2.

NADA-green is a fluorescent D-amino acid for labeling peptidoglycans in live bacteria.

ONO-8711 is a selective EP1 antagonist.

Galloflavin Potassium is an inhibitor of lactate dehydrogenase.

DTCBPy is an efficient thermally activated delayed fluorescence (TADF) molecule.

DCAI hydrochloride is an inhibitor of nucleotide exchange and nucleotide release, by binding to the pocket adjacent to the Ras-SOS interface.

Sulindac Sulfide is a metabolite of sulindac.

Gentamicin X2 Sulfate is a potent premature stop codon readthrough molecule and the common precursor of the gentamicin C antibiotic complex.

DBHDA is a reagent to convert a Cys into a Dha moiety by reacting with a C-terminal Cys residue and thus allowing the use of recombinant Ubl G76C mutants to prepare probes.

Bortezomib-pinanediol is a prodrug of Bortezomib, as well as a proteasome inhibitor.

4-Octyl Itaconate is a cell permeable activator of Nrf2 which inhibits LPS-induced increases in IL-1β mRNA, HIF-1α, and IL-10 in macrophages.

Arzanol is a positive modulator of brain glycogen phosphorylase.

BV02 is an inhibitor of SFN. It also targets YWHAZ of the 14-3-3 protein family.

Salicyl-AMS is a MbtA Inhibitors and Antimycobacterial Agent. salicyl-AMS [5'-O-(N-salicylsulfamoyl)adenosine] inhibits M. tuberculosis growth in vitro under iron-limited conditions.

Flumethasone 21-acetate is an anti-inflammatory corticosteroid.

Diflorasone Diacetate is a topical glucocorticoid with anti-inflammatory and immunosuppressive properties.

Isoflupredone Acetate is a topical anti-inflammatory corticosteroid.

MDL-800 is a first-in-class cellularly active SIRT6 allosteric activator.

JNJ-10191584 maleate is a highly selective histamine H4 receptor silent antagonist.

INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity.

3-Cl-DPA is an activator of cardiac troponin by a mechanism distinct from bepridil or TFP.

Rifamycin is a natural antibiotic which inhibits prokaryotic DNA-dependent RNA synthesis and protein synthesis, thereby blocking RNA-polymerase transcription initiation.

CBHA is a histone deacetylase (HDAC) inhibitor which potently induces transformed cell growth arrest and terminal differentiation.

DO1, also known as Disperse Orange 1, is an anti-amyloid agent which potently delays both seeded and non-seeded Aβ42 polymerization at substoichiometric concentrations, thereby disrupting preformed fibrillar assemblies of synthetic Aβ42 peptides.

6-PNG is a Cav3.2 (T-type) calcium channel blocker.

Pirenoxine, also known as Catalin, is an anti-cataractogenesis agent which interacts with selenite or calcium ions that have been proven as factors leading to the formation of lens cataract.

Valerenic acid is a ?-subunit-dependent GABAA receptor modulator.

Cytochalasin E is a natural autophagy inhibitor which enhances chemotherapy-induced cell death. Cytochalasin E is an epoxide-containing analog of Cytochalasin B which potently and selectively inhibits the growth of endothelial cells, thereby impairing angiogenesis and tumor growth. Unlike Cytochalasin A and Cytochalasin B, it does not inhibit glucose transport.

Chlorphenoxamine HCl is an antihistaminic agent which reverses multidrug resistance in L1210 tumor cells.