Seretide is a combination of fluticasone and salmeterol that is used as an inhaler formulation to manage the symptoms of asthma and chronic obstructive pulmonary disease (COPD).

Aminoluciferin is a luciferin derivative as functional bioluminogenic substrate.

Auxin is a plant hormone growth regulator.

Indican is a natural protective agent to the liver.

Monoelaidin is an enhancer of the solubility and oral bioavailability for poorly water-soluble drugs.

5-Methylcytosine is a methylated cytosine. It acts as a ligand of the hDNMT1.

S32826 is an inhibitor of autotaxin.

TPCK is a non-specific irreversible inhibitor of serine/cysteine proteases. It acts by inhibiting ScRce1 in the presence of a Ras reporter, but not in the presence of the a-factor peptide.

CP-96345 is a potent and selective non-peptide NK1 receptor antagonist.

Digitoxigenin is a precursor of cardiac glycosides. It acts by targeting the metastatic uveal melanoma gene signature.

p-BrBzGSH(Cp)2 is an inhibitor of glyoxylase 1 (GLO1). It acts by increasing DNA-AGEs, stimulating RAGE expression, and inhibiting brain tumor growth in orthotopic mouse models.

Methylenebis is an autophagy-regulator. It acts by sensitizing tumor cells to belotecan, a derivative of camptothecin, as a topoisomerase I inhibitor.

Ectoine is an inhibitor of protein misfolding. It acts by significantly down-regulating Syp, Mapk3 and Tnfα and up-regulating Vegf in rat's hippocampus, prohibiting insulin amyloid formation in vitro.

Trimosulfa is a fixed antibiotic combination. It is widely used for mild-to-moderate bacterial infections and as prophylaxis against opportunistic infections.

JR-AB2-011 is a potent and selective inhibitor of mTORC2 kinase activity. It markedly reduces mTORC2 signaling and IC50 while enhancing apoptotic levels in GBM cells.

TASIN-1 Hydrochloride is a truncated APC selective inhibitor. It acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.

MG-115(MG 115) is an inhibitor of NFκB in the cytoplasm by acting on IKK or the proteasome.

KLH45 is a selective inhibitor of DDHD2 (DDHD domain containing 2).

BSBM7 is an inhibitor of Aβ aggregation and neuronal toxicity. It acts by reversing the aggregation and toxicity of amyloid-β (Aβ) peptides.

Amodiaquin dihydrochloride is an inhibitor of the Ebola virus. It acts by targeting the viral protein 35 (VP35).

TLCK hydrochloride is a blocker of the LPS- or cytokine-induced activation of nuclear factor κB (NF-κB).

SKF-10047 is a sigma-1 receptor agonist.

GW438014A is a selective NPY-Y5 receptor antagonist.

Ractopamine HCl is a beta-Adrenergic agonist. It acts by being a full agonist at the TAAR1.

Ipsapirone, also known as BAY q 7821, is a new pyrimidinylpiperazine ligand potent and specific for 5-HT1A receptors. Ipsapirone hydrochloride has potential therapeutic use in affective disorders.

Oxolinic acid is an inhibitor of DNA-gyrase (topoisomerase II). It acts by inhibiting dopamine reuptake.

CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca2+ in HeLa cells expressing S1P3 receptors[1].

Naloxonazine Dihydrochloride is a potent and selective antagonist for μ1 opioid receptors.

NIDA-41020 is a CB1 cannabinoid receptor antagonist.

IM-54 is a cell permeable, potent and selective inhibitor of necrosis.

GSK837149A is the first selective inhibitor of human fatty acid synthase (FAS).

NSC-33994 is a selective inhibitor of JAK2.

Ridaifen-B is a tamoxifen derivative. It acts by inducing Bcl-2 independent autophagy without estrogen receptor involvement.

Methylarbutin is an ice recrystallization inhibitor (IRI).

ARDP0006 is a NS2B-NS3 protease inhibitor.

VLX600 is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells.

Tyrphostin 1 is an EGFR tyrosine kinase inhibitor.

KS370G is an inhibitor of UUO-induced renal fibrosis markers expression. It acts by attenuating collagen deposition in the obstructed kidney and significantly lowering the expression of renal inflammatory chemokines/adhesion molecules and monocyte cells marker.

UNC2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).

Flu-IA is a fluorescent probe that covalently labels DNA fragments.

NP-313 is an antithrombotic agent with dual inhibition of thromboxane A2 synthesis and calcium entry.

PK-THPP is a TASK-3 channel blocker.

TMCB is a dual-kinase inhibitor. It acts by inhibiting both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8).

UCF-101 is a selective inhibitor of the pro-apoptotic mitochondrial serine protease Omi/HtrA2 involved in the cellular response to thermal and oxidative stress.

ZINC05626394 is a Cytochrome b5 reductase 3 (CYB5R3) inhibitor. It acts by increasing NO bioavailability.

SPP-86 is a potent RET inhibitor.

CKI-7 2HCl is a casein kinase 1 (CK1) inhibitor.

NHI-2 is a LDHA inhibitor. It acts by reducing lactate production in HeLa cells.

Methylstat is an inhibitor of the Jumonji C domain-containing histone trimethyl demethylases (JHDMs).

TRIM is an nNOS inhibitor.

Lovastatin Sodium is an inhibitor of HMG-CoA reductase.

OG-L002 HCl is an inhibitor of LSD1.

Buserelin Acetate is a Gonadotropin-releasing hormone agonist (GnRH agonist).

2-MeS-ADP is a purinergic agonist. It acts by displaying selectivity for P2Y1, P2Y12 and P2Y13 receptors and inhibiting cAMP accumulation.

6-OHDA HBr is a neurotoxin. It acts by destroying catecholaminergic terminals.

AQ4 is a topoisomerase II inhibitor and DNA intercalator.

Quinpirole dihydrochloride is a D2-like dopamine receptor agonist.

(+)-Pinanediol is an effective inducer of melanogenesis. It acts by inducing higher levels of pigmentation and synthesis of nitric oxide (NO) in S91 cells.

GSNO is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. It acts by regulating diverse protein functions

BRD6688 is a selective HDAC2 inhibitor. It acts by enhancing the learning and memory processes.

Adenosine N1-oxide is an inhibitor of secretion of inflammatory mediators. It acts by suppressing pro-inflammatory cytokine secretion.

UCD38B HCl is a cell permeable inhibitor of intracellular uPA (urokinase plasminogen activator). It acts by killing proliferative and non-proliferative high grade glioma cells by programmed necrosis.

NPY5RA972 is a neuropeptide Y Y5 antagonist.

BAMF is an acetylating agent for the chemical modification of proteins.

alphaSYN-IN-NAB2 is an inhibitor of α-synuclein mutations. It acts by reversing the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons and promoting E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport..

1,4-DPCA is a potent and selective inhibitor of prolyl 4-hydroxylase.

3-HIB is a paracrine regulator of trans-endothelial fatty acid transport.

Dexanabinol is a cannabinoid agonist.

Wee1 Inhibitor I is an ATP-binding site-targeting inhibitor of Wee1.

FRJ is a specific inhibitor of protein tyrosine phosphatase 1B (PTP1B).

RA-2 is a pan-negative-gating modulator of KCa2/3 channels. It acts by inhibiting EDH-type relaxation in coronary arteries.

TT01001 is a mitoNEET ligand. It acts by improving diabetes and ameliorates mitochondrial function in db/db mice.

Fenoterol is β2-Adrenergic receptor (β2-AR) agonist. Fenoterol is chemically closely related to metaproterenol (orciprenaline). It has a higher bronchodilating potency than metaproterenol, albuterol (salbutamol in Europe) or terbutaline. The beta 2 selectivity of fenoterol at normal oral and inhaled doses is the same as for albuterol and terbutaline. Its pharmacodynamic effects are similar to those of other selective beta 2-adrenoceptor agonists.

SAFit2 is a selective inhibitor of the ?FK506-binding protein 51 (FKBP51).

NAV 26 (compound 26) is a selective voltage-gated sodium channel Nav1.7 blocker with an IC50 of 0.37 μM. NAV 26 can be used for pain research.

Indatraline HCl is a potent inhibitor of dopamine, norepinephrine and serotonin uptake.

KT185 is the first orally-active ABHD6-selective inhibitor. It displays excellent selectivity against other brain and liver serine hydrolases in vivo.

TC-E 5002 is a selective histone demethylase KDM2/7 subfamily inhibitor.

SR-3576 is a potent JNK3 inhibitor that is highly selective over p38.

MS438 is a potent agonist of the TSH receptor (TSHR).

CJB-090 2HCl is a dopamine D3 receptor partial agonist.

Methiothepin Maleate is an inhibitor of HCV infection and cell-to-cell transmission that acts by targeting the HCV E2 glycoprotein.

S-Fcme is a multidrug resistance transporter activator. It acts by stimulating the multidrug resistance transporter ATPase activity and competing for drug binding.

Cellocidin is a potent growth inhibitor for gammaherpesvirus-associated B-lymphomas that acts through activation of both the NF-κB and c-Myc-mediated signaling pathways.

TN-16 is a tubulin inhibitor.

TC-A2317 HCl is an Aurora kinase A inhibitor.

HNHA is a histone deacetylase (HDAC) inhibitor.

Rubone is a modulator of the tumor suppressor miRNA-34a. It acts by inhibiting the growth of hepatocellular carcinoma.

Arylquin-1 is a secretagogue of prostate apoptosis response-4 (Par-4). It acts by displacing Par-4 from vimentin for secretion and triggering the efficient paracrine apoptosis of diverse cancer cells.

NSC756093 is the first inhibitor of the GBP1:PIM1 interaction.

AH-7614 is a selective free fatty acid receptor 4 (FFA4/GPR120) antagonist.

Piperlonguminine is an inhibitor of Akt/mTOR signalling. It acts by promoting autophagy and mediating cancer cell death.

MK6-83 is an agonist of the transient receptor potential channel ML3 (TRPML3).

NBI-35965 Mesylate is a potent and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist.

WST-1 is a chromogenic indicator for NADH.

Bz-423 is an F1F0-ATPase modulator. It acts by selectively killing autoimmune lymphocytes.

Akt Inhibitor X is a cell permeable, reversible, and selective Akt phosphorylation inhibitor.

DEHP is an inducer of cell proliferation in lymphocytes.

Dolasetron mesylate is a selective 5-HT3 receptor antagonist.

VPC-14228 is a specific inhibitor of AR-DBD. It acts by inhibiting both Y594A and Q592A mutants, blocking the interaction of the AR with androgen response elements in the nucleus..

Pyrazofurin is an inhibitor of human dyskerin. It is also an antiviral agent.

SG-209 is a potassium channel opener.

ITX3 is a nontoxic selective cell active inhibitor of the Trio/RhoG?/Rac1 pathway. It acts by validating RhoGEFs as druggable targets.

BML-266 is a sirtuin inhibitor. It acts by inducing granulocytic differentiation in the acute promyelocytic leukemia (APL) cell line NB4.

DCAI is an inhibitor of nuleotide exchange and nucleotide release. It acts by binding to the pocket adjacent to the Ras-SOS interface.

TFMB-(R)-2-HG is a cell membrane-permeable version of (R)-2-HG that acts as a promoter of leukemogenesis, dose-dependently and passage-dependently blocking differentiation.

WAY-208466 2HCl is a selective serotonin 5-HT6 receptor agonist.

Pyrintegrin is a cell-permeable promoter of the adhesion of individually dissociated hESCs on matrigel- or laminin-, but not gelatin-coated surfaces, substantially reducing trypsinization-induced apoptosis.

TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor.

TSI-01 is a selective inhibitor of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2 (LPCAT2).

CAY10589 is an inhibitor of mPGES-1.

HLM006474 is a pan-E2F inhibitor. It inhibits DNA binding to E2F1, E2F2, and E2F4 in A375 melanoma cells when used at a concentration of 40 μM.

NAD-299 HCl is a high affinity 5-HT1A receptor antagonist.

Arcyriaflavin A is an inhibitor of cdk4/cyclin D1 and CaM kinase II.

MP265 is an inhibitor of MreB polymerization.

LT175 is a PPARα/γ ligand with potent insulin sensitizing effects and reduced adipogenic properties.

AG1478 HCl is an inhibitor of epidermal growth factor receptor protein.

GPBAR-A is a bile acid receptor TGR5 (GPBA) agonist.

Creatine riboside is the strongest classifier of lung cancer status in all and stage I-II cases, important for early detection, and also associated with worse prognosis in stage I-II lung cancer.

MDK5466, also known as Flt3 Inhibitor III, is a Flt3 inhibitor that acts by preventing glutamate-induced cell death. MDK5466 has CAS#852045-46-6. For the convenience of scientific communication, we temporally name it as MDK5466. The last four digit of the CAS# was used in the name.

BRD32048 is an inhibitor of the ETV1 transcription factor oncoprotein.

MIR96-IN-1 is a selective inhibitor of the biogenesis of microRNA-96. It acts by upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.

JMC-4 is a 5-LOX inhibitor.

LUF5834 is a potent nonribose agonist, activating A2A and A2B adenosine receptor.

Diclofensine HCl is an antidepressant with equipotent inhibitive effects on the neuronal uptake of norepinephrine (NE), serotonin, and dopamine.

N-Acetylpurinomycin is a selective CB2 receptor agonist.

VU0071063 is an activator of Kir6.2/SUR1.

Rhodblock 6 is an inhibitor of the Rho pathway. It acts by specifically abrogating Rho kinase activity.

Zearalenone is a mycotoxin produced by Fusarium. It acts by binding the estrogen receptor (ER).

DNDS is a voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR) channel blocker.

RO8191 is an activator of JAK/STAT that induces IFN-like signals.

Ononetin is a TRPM3 channel blocker.

Sulbutiamine is an antioxidant that act by inhibiting oxidative stress induced retinal ganglion cell death.

MRE 3008-F20 is a potent antagonist of the human A3 adenosine receptors.

o-3M3FBS is a negative control for m-3M3FBS, an activator of phospholipase C (PLC).

m-3M3FBS is an activator of phospholipase C (PLC). It acts by stimulating superoxide generation, Ca2+ release and inositol phosphate formation in a variety of cell types.

DHQ is an inducer of ATPase activity of Herpes Simplex Virus thymidine kinase.

GRK2 Inhibitor is an inhibitor of GRK 2 (β-Adrenergic Receptor Kinase 1).

MMPIP HCl is an allosteric mGlu7-selective receptor antagonist.

ACPT-1 is an agonist of group III mGlu receptors.

AMPK activator D942 is a cell-permeable activator of AMPK.

N2-OH-PhIP is a PhIP metabolite.

N12N is a polyamine inverse agonist of NMDA receptor.

PMX464 is a cytocidal anti-trypanosomal inhibitor that acts by targeting trypanothione metabolism. It is also a putative inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system.

Qc1 is a reversible, non-competitive inhibitor of threonine dehydrogenase (TDH).

Norchlorcyclizine is a partially selective NPR-B inhibitor. It also acts as an inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1).

3AC is an inhibitor of SH2 domain-containing inositol-5’-phosphatase 1 (SHP-1). It is selective for SHP-1 over SHP-2 and phosphatase and tensin homolog (PTEN). 3α-Aminocholestane induces hyperactivation of the tyrosine kinase SYK in patient-derived Ph+ acute lymphoblastic leukemia (ALL) cells and selectively induces cytotoxicity in these cells over mature B cell lymphoma cells. It reduces leukemia burden and increases survival in a tyrosine kinase inhibitor-resistant patient-derived Ph+ ALL mouse xenograft model when administered at a dose of 50 mg/kg. 3α-Aminocholestane reduces cell viability of OPM2 multiple myeloma (MM) cells in a concentration-dependent manner and of RPMI8226 MM cells when used at concentrations greater than or equal to 12.5 μM. It halts the cell cycle at the G0/G1 or G2/M stages in the highly proliferative OPM2 or less proliferative RPMI8226 cell lines, respectively. It induces apoptosis via activation of caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP) in OPM2 cells but not in RPMI8226 cells. 3α-Aminocholestane reduces tumor burden and increases survival in an OPM2 mouse xenograft model.

SMI481 is the first small-molecule inhibitor of Sec14-like phosphatidylinositol transfer proteins (PITPs).

Phox-I2 is a second generation inhibitor of the p67phox interaction with Rac1, effective in suppressing reactive oxygen species production by human and murine neutrophils.

YN1 is a PFKFB3 inhibitor.

IDO1-IN-1 is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1).

NQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide (41GCWMLY46 within the N-terminus of γD-crystallin) as well as full-length γD-crystallin.

DTNB is an allosteric inhibitor of the NS2B-NS3 protease from dengue virus. It acts as a reagent for the determination of reactive sulfhydryl groups.

RTC13 is a premature termination codon (PTC) readthrough inducer that acts by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy.

Paroxetine maleate is a selective serotonin reuptake inhibitor and an antidepressant.

ML336 is an inhibitor of of the Venezuelan equine encephalitis virus (VEEV) strain TC-83.

MAL2-11B is an inhibitor of Simian Virus 40 replication. It acts by targeting the molecular chaperone function and ATPase activity of T antigen. MAL2-11B is also a MAL3-101 precursor.

CCCI-01 is an inhibitor of centrosome clustering in cancer cells.

C527 is a inhibitor of USP1 target ID1 degradation in leukemic cells.

JCP174 is an inhibitor of a depalmitoylase that enhances Toxoplasma host-cell invasion by targeting TgPPT1.

BVT.13 is a selective PPAR-gamma activator.

R(+)-SKF-38393A is a D1 dopamine receptor agonist. It is also a more active enantiomer of (±)-SKF-38393A.

Amiloride HCl anhydrous is a Na+ channel blocker. It acts by blocking TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger.

(R)-Pantetheine is a metabolite in carbapenem biosynthesis, pantothenate and CoA biosynthesis and biosynthesis of secondary metabolites.

(-)-Quinpirole HCl is the most widely used D2 agonist in in vivo and in vitro studies.

Ro 41-0960 is a reversible and orally-active COMT-inhibitor.

R(+)-6-Bromo-APB HBr is a potent D1 Dopamine receptor agonist.

NeuroSensor 521 is a fluorescent turn-on sensor. It acts by binding catecholamines such as dopamine and norepinephrine more tightly than other biogenic amines such as glutamate and does not interact with secondary amines such as epinephrine.

NTE-122 is a potent, selective and competitive inhibitor of Acyl-CoA:cholesterol acyltransferase (ACAT).

MB-3 is a histone acetyltransferase GCN5 inhibitor.

MSX-2 is a selective A2A adenosine receptor antagonist.

MDL-12330A is an inhibitor of adenylyl cyclase. It acts by inhibiting cAMP and cGMP phosphodiesterases and blocking slow extracellular and store-operated Ca2+ entry into cells.

Necrostatin-7 is a necroptosis inhibitor. It acts by inhibiting TNF-alpha-induced necroptosis in a FADD-deficient variant of human Jurkat T cells.

T62 is an allosteric enhancer of A1 adenosine receptor.

Daporinad, also known as APO-866 and FK866, is a small molecule with potential antineoplastic and antiangiogenic activities. NMPRTase inhibitor APO866 binds to and inhibits nicotinamide phosphoribosyltransferase (NMPRTase), inhibiting the biosynthesis of nicotinamide adenine dinucleotide (NAD+) from niacinamide (vitamin B3), which may deplete energy reserves in metabolically active tumor cells and induce tumor cell apoptosis. In addition, this agent may inhibit tumor cell prioduction of vascular endothelial growth factor (VEGF), resulting in the inhibition of tumor angiogenesis.

EBPC is a potent aldose reductase inhibitor.

8-Br-cGMP is an activator of cGMP-dependent protein kinase. It acts by inhibiting the intracellular calcium oscillations of tracheal smooth muscle cells in response to acetylcholine.

CX-6258 HCl is a potent, selective, and orally efficacious pan-Pim kinases inhibitor.

SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor.

MeBIO is a negative control analog of BIO, and an aryl hydrocarbon receptor (AhR) agonist. It causes redistribution of AhR to the nucleus.

Arg-Gly-Asp is a primary sequence in cellular recognition. It is involved with the binding of proteins to cell surfaces and has strong affinity and selectivity to the alpha(V)beta(3) integrin receptors.

U-99194 maleate is a potent, selective D3 antagonist.

AM-404 is a selective inhibitor of the carrier-mediated transport of anandamide without affecting anandamide hydrolysis.

Cirazoline HCl is a selective alpha1-adrenoceptor agonist and a non-selective imidazoline binding site ligand.

Nor-SCH-12679 Maleate is a D1-dopamine receptor antagonist.

Muscimol HBr is a GABAA receptor agonist.

NAEPA is a selective lysophosphatidic acid-1 (LPA1) receptor agonist and a LPA mimetic.

PQ1 Succinate is a gap junction enhancer. It acts by restoring GJIC and increasing connexin expression in breast cancer cell lines while not affecting normal mammary cells.

Pyr3 is a selective antagonist of the canonical transient receptor potential channel 3 (TRPC3).

AC-93253 iodide is a SIRT2 selective inhibitor. It acts by significantly enhancing acetylation of tubulin, p53, and histone H4.

S3QEL-2 is a modulator of the retrograde signaling. It acts by strongly mitigating the oxidative stress-induced apoptosis that limits the yield of functional ?-cells from intact islets.

2002-H20 is an inhibitior of Aβ42-induced cytotoxicity. It acts by binding the Alzheimer's Aβ peptide and reducing its cytotoxicity.

EIPA is a selective blocker of Na+/H+ antiport.

A1899 is a potent and selective TASK-1 and TASK-3 antagonist.

L-NMMA acetate is an endothelium-derived relaxing factor inhibitor. It acts by inhibiting the generation of NO from arginine.

Brilliant Blue G is a P2X7 purinergic receptor antagonist.

AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and potentiating DNA-targeted therapies.

Dicyclanil is an insect growth regulator.

XRP44X is a potent Ras-Net (Elk-3) pathway inhibitor.

Tyrphostin AG957 is a tyrosine kinase inhibitor, selectively inhibiting human p210 tyrosine kinase activity.