BIO-8169 is a highly potent, selective, and brain-penetrant IRAK4 inhibitor with IC50 of 0.2 nM. BIO-8169 has an excellent PK profile, reduces the in vivo production of pro-inflammatory cytokines, and is tolerated in toxicity studies in rodents and dogs.

Nelutroctiv (CK-136) is a novel cardiac troponin activator devoid of PDE-3 activity that demonstrates a wider pharmacodynamic window in vivo relative to a representative myosin activator, CK-138.

TAC is a TERT activator compound that upregulates TERT transcription via the MEK/ERK/AP-1 cascade. TAC alleviates neuroinflammation, increases neurotrophic factors, stimulates adult neurogenesis, and preserves cognitive function without evident toxicity, including cancer risk.

GalNAc-L96-tert-butyl ester is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG/Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.