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VH032-C3-NH2((S,R,S)-AHPC-C3-NH2)

  Cat. No.:  DC50058   Featured
Chemical Structure
2361119-88-0
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Field of application
(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852. UNC6852 is an EED-targeted bivalent chemical degrader[1].
Cas No.: 2361119-88-0
Chemical Name: (S,R,S)-Ahpc-C3-NH2
Synonyms: (S,R,S)-AHPC-C3-NH2;VH032-C3-NH2;BCP33427;(2S,4R)-1-((S)-2-(4-aminobutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
SMILES: S1C=NC(C)=C1C1C=CC(=CC=1)CNC([C@@H]1C[C@H](CN1C([C@H](C(C)(C)C)NC(CCCN)=O)=O)O)=O
Formula: C26H37N5O4S
M.Wt: 515.668084859848
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC39625 (S,R,S)-AHPC-PEG4-NH2 hydrochloride VH 032 Linker 2 is a derivative of the proteolysis-targeting chimera technology (PROTAC) building block VHL ligand 1.
DC50079 Thalidomide-O-amido-C5-NH2 Thalidomide-O-amido-C5-NH2 is a novel PROTAC building block.
DC50078 (S,R,S)-AHPC-Me-C8-NH2 (S,R,S)-AHPC-Me-C8-NH2 is a novel PROTAC building block.
DC50077 (S,R,S)-AHPC-Me-C4-NH2 (S,R,S)-AHPC-Me-C4-NH2 is a novel PROTACA building block.
DC50076 (S,R,S)-AHPC-Me-C3-NH2 (S,R,S)-AHPC-Me-C3-NH2 is a novel PROTAC building block.
DC50075 (S,R,S)-AHPC-Me-C2-NH2 (S,R,S)-AHPC-Me-C2-NH2 is a novel PROTAC building block.
DC50074 (S,R,S)-AHPC-Me-C1-NH2 (S,R,S)-AHPC-Me-C1-NH2 is a novel PROTAC Building block.
DC50070 (S,R,S)-AHPC-PEG2-NH2 (E3 ligase Ligand-Linker Conjugates 6 Free Base) (S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
DC50069 (S,R,S)-AHPC-PEG4-NH2(E3 ligase Ligand-Linker Conjugates 7) (S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
DC50068 (S,R,S)-AHPC-Me-C10-NH2 (S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432
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