| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC71033 | EC144 | EC144 is a potent and selective inhibitor of heat shock protein 90 (Hsp90) with an IC50 of 1.1 nM. EC144 inhibits tumor growth and causes partial tumor regressions. EC144 has the potential for the research of cancer diseases. |
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| DC71045 | FT709 Featured | FT709 is a potent and selective USP9X inhibitor, an IC50 of 82 nM. USP9X has been linked with centrosome function, chromosome alignment during mitosis, EGF receptor degradation, chemo-sensitization, and circadian rhythms. |
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| DC71081 | MG-262 | MG-262 is a reversible proteasome inhibitor with diverse biological activities. |
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| DC71202 | Macbecin | Macbecin is a stable HSP90 inhibitor by binding to the ATP-binding site with an IC50 of 2 μM and a Kd of 0.24 μM. Macbecin exhibits antitumor and cytocidal activities. |
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| DC71617 | Suc-Gly-Gly-Phe-pNA | Suc-Gly-Gly-Phe-pNA is the chymotrypsin substrate with an Km value of 1.6 mM. |
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| DC71668 | Iu1-248 Featured | Iu1-248, a derivative of IU1, is a potent and selective ubiquitin specific peptidase 14 (USP14) inhibitor with an IC50 of 0.83 μM. |
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| DC71907 | 20S Proteasome activator 1 | 20S Proteasome activator 1 is a potent 20S proteasome activator with EC200 values of 0.3 μM, 0.7 μM and 1.8 μM for trypsin-like site, chymotrypsin-like site and caspase-like site. 20S Proteasome activator 1 translates well in a cellular system, preventing the accumulation of the pathogenic A53T mutant of α-synuclein. 20S Proteasome activator 1 can be used for researching neurodegenerative diseases. |
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| DC72094 | Ac-PAL-AMC | Ac-PAL-AMC is a fluorogenic substrate specific for 20S proteasome LMP2/β1i activity. |
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| DC72095 | Ac-WLA-AMC | Ac-WLA-AMC is a specific 20S constitutive proteasome β5 fluorogenic substrate. |
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| DC72096 | NIC-0102 | NIC-0102 is an orally active proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammatory vesicle activation. NIC-0102 shows potent anti-inflammatory effects in a model of dextran sulfate sodium (DSS)-induced ulcerative colitis. NIC-0102 also inhibits production of pro-IL-1β. |
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| DC72120 | Teslexivir hydrochloride | Teslexivir (BTA074) hydrochloride is a potent antiviral agent. Teslexivir hydrochloride is a potent and selective inhibitor of the interaction between two essential viral proteins, E1 and E2, an association that is a necessary step in the DNA replication and thus viral production for Human Papilloma Virus (HPV) 6 and 11. Teslexivir hydrochloride can be used for condyloma research. |
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| DC72125 | KU-177 | KU-177 is a potent inhibitor of Hsp90 ATPase homologue 1 (Aha1), ablates Aha1-driven enhancement of Hsp90-dependent tau aggregation. KU-177 also disrupts Aha1/Hsp90 interactions (IC50=4.08 μM) without inhibition of Hsp90’s ATPase activity. KU-177 can be used for tauopathies research. |
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| DC72255 | 8RK64 | 8RK64 is a covalent UCHL1 inhibitor (IC50: 0.32 μM). |
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| DC72773 | Brigimadlin Featured | Brigimadlin is an E3 ubiquitin-protein ligase MDM-2 inhibitor. Brigimadlin serves as an antineoplastic agent. |
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| DC72826 | Usp22i-S02 Featured | Usp22i-S02(USP22-IN-1, compound S02) is a potent inhibitor of ubiquitin specific peptidase 22 (USP22). It showed anticancer activity by suppressing Foxp3 expression in T-regulatory cells. |
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| DC74272 | BAY-728 | BAY-728 (NAY728) is a less potent enantiomer and negative control compound of BAY-805. |
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| DC74273 | BK50118-C | BK50118-C is a potent small molecule inhibitor of ubiquitin-specific protease-13 (USP13) with IC50 of 0.42 nM. |
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| DC74274 | BML-260 | BML-260 (BML260) is a potent inhibitor of dual-specific phosphatase JSP-1 (JNK Stimulatory Phosphatase-1, DUSP22) and stimulator of uncoupling protein 1 (UCP-1) expression in adipocytes. |
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| DC74275 | C598-0556 | C598-0556 is a selective, small molecule inhibitor of USP10, inhibits USP10 comparably to HBX19818 (IC50=10 uM), with no inhibition against USP7 (IC50>100 uM). |
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| DC74276 | C673-0105 | C673-0105 is a selective, small molecule inhibitor of USP10, inhibits USP10 comparably to HBX19818 (IC50=10 uM), with no inhibition against USP7 (IC50>100 uM. |
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| DC74277 | CAS-12290-201 | CAS-12290-201 is a potent and selective inhibitor of deubiquitinating enzyme (DUB) VCPIP1 with IC50 of 70 nM, covalently and specificly targets the catalytic cysteine of VCPIP1 with little to no activity toward other cellular DUBs. |
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| DC74278 | DC-U4106 | DC-U4106 is a potent, selective small molecule inhibitor of Ubiquitin-specific protease 8 (USP8) with binding KD value of 4.7 uM, DC-U4106 is selective over USP2 and USP7. |
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| DC74279 | FT206 | FT206 (FT-206, FT3951206, CRT0511973) is a potent, selectivel inhibitor of USP28 with a remarkable USP28/25 selectivity. |
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| DC74280 | FT385 | FT385 (FT3967385) is a potent, selective USP30 inhibitor with biochemical IC50 of 1.5 nM. |
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| DC74281 | GK13S | GK13S is a highly potent, specific and covalent inhibitor of deubiquitinase UCHL1 with IC50 of 87 nM, displays exquisite specificity for UCHL1 over the other UCH family members (IC50>10 uM). |
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| DC74282 | HY041004 | HY041004 is the first small molecule inhibitor of deubiquitinase Josephin Domain-containing protein 2 (JOSD2) with IC50 of 0.26 uM for JOSD2 catalytic activity inhibition. |
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| DC74283 | I-138 | I-138 (I 138) is a potent, specific small molecule USP1-UAF1 inhibitor with IC50 of 4.1 nM, binds to USP1-UAF1 at an allosteric pocket synergistically with ubiquitin. |
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| DC74284 | IMP-2373 | IMP-2373 is a highly targeted cyanopyrrolidine (CNPy) probe for pan-DUB to monitor DUB activity in physiologically relevant live cells. |
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| DC74285 | IU1-206 | IU1-206 is a IU1 derivative with more potent activity against USP14, 10-fold more potent than IU1 and is comparable to the IU1-47. |
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| DC74286 | IU2-6 | IU2-6 is a small molecule USP14 inhibitor, shows 74% inhibition at 8 uM. |
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