Cat. No. | Product name | CAS No. |
DC74409 |
Danatinib
Danatinib is a potent and selective FLT3 inhibitor with IC50 of 3 nM, overcomes acquired resistance and shows effective inhibition against FLT3-ITD and/or FLT3-TKD mutations. |
2250252-61-8 |
DC74410 |
MBP-11901
MBP-11901 is an orally active, multitarget tyrosine kinase inhibitor targeting FLT3, VEGFR2, PDGFRβ, and c-KIT, shows excellent inhibitory activity against HCC cell growth in vitro (HepG2, IC50=5.16 uM). |
2097149-62-5 |
DC74411 |
PCW-A1001
PCW-A1001 is a potent, selective inhibitor of FLT-3 (D835Y) mutant with IC50 of 764 nM, weakly inhibits WT FLT-3 with IC50 of 2.54 uM. |
|
DC74412 |
TSN084
TSN084 (TSN 084) is a unique small molecule multi-kinase inhibitor of drug-resistant mutations of c-Met, Trks, and Flt3, also inhibits other oncotargets including Axl, DDRs, and CDK8/19. |
2412309-60-3 |
DC74413 |
YHJ1039
YHJ1039 is a broad-spectrum kinase inhibitor, possesses excellent potencies against FLT3 mutants (FLT3 D835Y, IC50=0.41 nM) as well as FAK (IC50=7 nM). |
1644557-92-5 |
DC74414 |
BSJ-04-175
BSJ-04-175 is a potent, selective focal adhesion kinase (FAK, protein tyrosine kinase 2 or PTK2) inhibitor with biochemical IC50 of 22 nM, 30-fold selectivity over PYK2. |
2414478-49-0 |
DC74416 |
BM001
BM001 (BM-001) is a small molecular inhibitor of the integral growth hormone/insulin-like growth factor-1 (GH/IGF1) axis, shows potent antiproliferative effect on cancer cells MDA-MM-231 and Colo-205 with IC50 of 20-30 nM. |
189810-65-9 |
DC74417 |
GTX-134
GTx-134 (GTx 134) is a selective small-molecule inhibitor of IGF-1R and insulin receptor (IR) with biochemical IC50 of 97 nM and 187 nM, respectively. |
1356059-82-9 |
DC74418 |
GNE-4997
GNE-4997 is a potent and selective inhibitor of the interleukin-2-inducible T-cell kinase (ITK) with Ki of 0.09 nM. |
1705602-02-3 |
DC74419 |
JTE-051
JTE-051 (JTE051) is a potent, selective inhibitor of interleukin-2-inducible T cell kinase (ITK), suppresses overactive immune response via inhibition of the signal to activate T cells related to immune response. |
1309784-09-5 |
DC74420 |
HSN608
HSN608 (HSN 608) is a potent inhibitor of RET solvent-front mutants, inhibits RET G810 solvent-front mutants and the V804M gatekeeper mutant with IC50 of <50 nM in cell culture, inhibits ABL1(T315I) with IC50 of 40.7 nM. |
2234239-90-6 |
DC74421 |
TG 100801
The prodrug of TG 100572, a potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family. |
867331-82-6 |
DC74422 |
BI 1342561
BI 1342561 is a novel potent and selective SYK inhibitor developed to treat severe asthma. |
2088840-19-9 |
DC74423 |
BI 894416
BI 894416 is a novel potent and selective SYK inhibitor developed to treat severe asthma. |
1810059-82-5 |
DC74424 |
MRL-SYKi
MRL-SYKi is a potent, selective inhibitor of Syk (Spleen tyrosine kinase) with IC50 of <100 nM, also potently inhibits ZAP70 (24 nM in vitro). |
1312534-69-2 |
DC74425 |
MTX-216
MTX-216 (MTX216) is a dual PI3K/EGFR inhibitor that blocks neurofibromin 1 loss of function (NF1LoF) melanoma cell growth in vitro and in vivo, suppresses the activity of SYK kinase with IC50 of 281 nM. |
1952236-19-9 |
DC74426 |
RDN009
RDN009 (RDN-009) is a potent, selective, and covalent ZAP-70 kinase inhibitor with IC50 of 55 nM. |
2839429-24-0 |
DC74427 |
RDN2150
RDN2150 is a potent, selective and covalent ZAP-70 inhibitor with IC50 of 14.6 nM, shows no significant activity against Syk, covalently binds to the C346 residue of ZAP-70. |
2839429-51-3 |
DC74428 |
Adrixetinib
Adrixetinib is a small molecule inhibitor of Axl/Mer RTK. |
2394874-66-7 |
DC74429 |
ER-851
ER851 (ER-851) is a potent and highly selective AXL inhibitor. |
|
DC74430 |
INCB081776
INCB081776 is a potent and selective dual inhibitor of AXL and MERTK with IC50 of 16 and 14 nM respectively, 30-fold selectivity over TYRO3. |
|
DC74431 |
R992
R992 (MERTK inhibitor) is a novel potent, selective and orally bioavailable inhibitor of Mer tyrosine kinase (MerTK) with IC50 of 18 nM in ADP-Glo assays. |
2171523-99-0 |