RDN2150

  Cat. No.:  DC74427  
Chemical Structure
2839429-51-3
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More than 5000 active chemicals with high quality for research!
Field of application
RDN2150 is a potent, selective and covalent ZAP-70 inhibitor with IC50 of 14.6 nM, shows no significant activity against Syk, covalently binds to the C346 residue of ZAP-70.
Cas No.: 2839429-51-3
Chemical Name: RDN2150
SMILES: O=C(C1=C(NC2=CC=C(N3CCOCC3)C(OC)=C2)N=C(NCC4=CC=C(Cl)C(NC(C=C)=O)=C4)N5C1=NC=C5)N
Formula: C28H29ClN8O4
M.Wt: 577.04
MSDS
Cat. No. Product name Field of application
DC48025 Cevidoplenib dimesylate Cevidoplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities.
DC40848 SRX3207 SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor. SRX3207 possesses anti-tumor activity.
DC74427 RDN2150 RDN2150 is a potent, selective and covalent ZAP-70 inhibitor with IC50 of 14.6 nM, shows no significant activity against Syk, covalently binds to the C346 residue of ZAP-70.
DC74426 RDN009 RDN009 (RDN-009) is a potent, selective, and covalent ZAP-70 kinase inhibitor with IC50 of 55 nM.
DC74425 MTX-216 MTX-216 (MTX216) is a dual PI3K/EGFR inhibitor that blocks neurofibromin 1 loss of function (NF1LoF) melanoma cell growth in vitro and in vivo, suppresses the activity of SYK kinase with IC50 of 281 nM.
DC74424 MRL-SYKi MRL-SYKi is a potent, selective inhibitor of Syk (Spleen tyrosine kinase) with IC50 of <100 nM, also potently inhibits ZAP70 (24 nM in vitro).
DC74423 BI 894416 BI 894416 is a novel potent and selective SYK inhibitor developed to treat severe asthma.
DC74422 BI 1342561 BI 1342561 is a novel potent and selective SYK inhibitor developed to treat severe asthma.
DC70447 GSK143 GSK143 is a highly potent, selective, orally efficacious Syk inhibitor with pIC50 of 7.5, >600-fold selective over ZAP-70; inhibits anti-IgM induced Erk1/2 phosphorylation in Ramos cells with pIC50 of 7.1, and anti-IgM induced CD69 surface expression in primary B cells with pIC50 of 6.6; shows good efficacy in the rat Arthus model.
DC48946 SYK/JAK-IN-1 SYK/JAK-IN-1 is dual SYK/JAK inhibitor with IC50s of <5 nM for SYK and JAK2, respectively.
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