BI 1342561|CAS 2088840-19-9|DC Chemicals

Cas No.:	2088840-19-9
Chemical Name:	BI 1342561
SMILES:	O=C1NC[C@H]([C@H](OC2=CC(C3=CN(C(C)(C)C)N=C3)=CC4=NN(C)C(C)=C24)C)C1
Formula:	C₂₂H₂₉N₅O₂
M.Wt:	395.51

MSDS

Cat. No.	Product name	Field of application
DC48025	Cevidoplenib dimesylate	Cevidoplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities.
DC40848	SRX3207	SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor. SRX3207 possesses anti-tumor activity.
DC74427	RDN2150	RDN2150 is a potent, selective and covalent ZAP-70 inhibitor with IC50 of 14.6 nM, shows no significant activity against Syk, covalently binds to the C346 residue of ZAP-70.
DC74426	RDN009	RDN009 (RDN-009) is a potent, selective, and covalent ZAP-70 kinase inhibitor with IC50 of 55 nM.
DC74425	MTX-216	MTX-216 (MTX216) is a dual PI3K/EGFR inhibitor that blocks neurofibromin 1 loss of function (NF1LoF) melanoma cell growth in vitro and in vivo, suppresses the activity of SYK kinase with IC50 of 281 nM.
DC74424	MRL-SYKi	MRL-SYKi is a potent, selective inhibitor of Syk (Spleen tyrosine kinase) with IC50 of <100 nM, also potently inhibits ZAP70 (24 nM in vitro).
DC74423	BI 894416	BI 894416 is a novel potent and selective SYK inhibitor developed to treat severe asthma.
DC74422	BI 1342561	BI 1342561 is a novel potent and selective SYK inhibitor developed to treat severe asthma.
DC70447	GSK143	GSK143 is a highly potent, selective, orally efficacious Syk inhibitor with pIC50 of 7.5, >600-fold selective over ZAP-70; inhibits anti-IgM induced Erk1/2 phosphorylation in Ramos cells with pIC50 of 7.1, and anti-IgM induced CD69 surface expression in primary B cells with pIC50 of 6.6; shows good efficacy in the rat Arthus model.
DC48946	SYK/JAK-IN-1	SYK/JAK-IN-1 is dual SYK/JAK inhibitor with IC50s of <5 nM for SYK and JAK2, respectively.