GW311616A

Cas No.:	197890-44-1
Chemical Name:	(3s,3as,6ar)-3-isopropyl-1-(methanesulfonyl)-4-[4-(1-piperidinyl)-2(e)-butenoyl]perhydropyrrolo[3,2b]pyrrol-2(1h)-one hydrochloride
Synonyms:	GW 311616A,GW-311616A
SMILES:	O=C1[C@@H](C(C)C)[C@@](N(C(/C=C/CN2CCCCC2)=O)CC3)([H])[C@]3([H])N1S(=O)(C)=O.[H]Cl
Formula:	C19H31N3O4S.ClH
M.Wt:	433.998
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

The HNE inhibitor GW311616A is selective over other human serine proteases (IC50 values >100 uM for trypsin, cathepsin G, and plasmin, >3 mM for chymotrypsin and tissue plasminogen activator). Acetylcholinesterase is not inhibited by GW311616A at 100 uM.GW311616A is more potent than thetrifluoromethylketone inhibitor ZD8321 (Ki=13 nM). GW311616A is orallybioavailable in rat, dog (Table 4) and hamster despite moderate to high plasmaclearance, which indicates that clearance is predominantly extrahepatic. For the detailed information of GW311616A, the solubility of GW311616A in water, the solubility of GW311616A in DMSO, the solubility of GW311616A in PBS buffer, the animal experiment (test) of GW311616A, the cell expriment (test) of GW311616A, the in vivo, in vitro and clinical trial test of GW311616A, the EC50, IC50,and affinity,of GW311616A, For the detailed information of GW311616A, the solubility of GW311616A in water, the solubility of GW311616A in DMSO, the solubility of GW311616A in PBS buffer, the animal experiment (test) of GW311616A, the cell expriment (test) of GW311616A, the in vivo, in vitro and clinical trial test of GW311616A, the EC50, IC50,and affinity,of GW311616A, Please contact DC Chemicals.