| DC48244 |
Delta-12-Prostaglandin J2 |
Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation. |
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| DC48245 |
3-Oxo-7-hydroxychol-4-enoic acid |
3-Oxo-7-hydroxychol-4-enoic acid is an endogenous metabolite. 3-Oxo-7-hydroxychol-4-enoic acid may be an important indicator of a poor prognosis in hepatobiliary disease. |
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| DC48246 |
4-Prenyloxyresveratrol |
4-Prenyloxyresveratrol, an oxyresveratrol derivative, shows potent tyrosinase inhibitory activity with an IC50 of 0.90 μM. |
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| DC48247 |
Paltimatrectinib |
Paltimatrectinib (compound I-147) is a potent tyrosine kinase inhibitor with an IC50 of <10 nM for tropomyosin kinases A (TrkA). Paltimatrectinib has the potential for cancer and inflammatory diseases. |
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| DC48248 |
PCSK9-IN-1 |
PCSK9-IN-1 is a novel and highly potent cyclic peptide PCSK9 inhibitor with a Ki value of 1.46 nM. |
|
| DC48249 |
APC-6860 |
APC-6860 is a trypsin-like serine proteases inhibitor with ki values of 0.21, 0.44, 1.5, 16.8, 20, 30 μM for uPA, trypsin, tryptase, tPA, thrombin and factor Xa, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has ki values of 0.1, 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer. |
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| DC48387 |
BACE1-IN-6 |
BACE1-IN-6 is a BACE1 inhibitor with an IC50 value of 1.5 nM. |
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| DC48403 |
Ftase inhibitor III |
Ftase inhibitor III is an anion-dependent Farnesyltransferase inhibitor from a phenotypic screen. |
|
| DC48421 |
SHP2 protein degrader-1 |
SHP2 protein degrader-1 is a potent allosteric inhibitor of SHP2. SHP2 protein degrader-1 induces SHP2 degradation and cell apoptosis. SHP2 protein degrader-1 has the potential for the treatment of SHP2 related diseases. |
|
| DC48430 |
gp91ds-tat |
gp91ds-tat, a peptide inhibitor for NADPH oxidase assembly, is composed of gp91phox sequence linked to the human immunodeficiency virus-tat peptide. The tat sequence facilitates the entry of this peptide into cells. |
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| DC48438 |
Upamostat (WX-671) |
Upamostat (WX-671), a novel serine protease urokinase (uPA) inhibitor by inhibiting the urokinase-type plasminogen activator (uPA) system. |
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| DC48442 |
L-Tryptophan-13C11,15N2 |
L-Tryptophan-13C11,15N2 (Tryptophan-13C11,15N2) is the 13C- and 15N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3. |
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| DC48443 |
L-Tryptophan-13C11 |
L-Tryptophan-13C11 (Tryptophan-13C11) is the 13C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3. |
|
| DC48444 |
Palmitoleic acid-13C16 |
Palmitoleic acid-13C16 is the 13C labeled Palmitoleic acid. Palmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats. |
|
| DC48446 |
Linoleic acid-13C18 |
Linoleic acid-13C18 is the 13C labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism . |
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| DC48448 |
Glycine-13C2,15N |
Glycine-13C2,15N is the 13C- and 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. |
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| DC48449 |
Glycine-13C2 |
Glycine-13C2 is the 13C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. |
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| DC48450 |
β-Alanine-13C3,15N |
β-Alanine-13C3,15N (2-Carboxyethylamine-13C3,15N) is the 13C- and 15N-labeled β-Alanine. β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer. |
|
| DC48451 |
L-Alanine-13C3,15N |
L-Alanine-13C3,15N (L-2-Aminopropionic acid-13C3,15N) is the 13C- and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system. |
|
| DC48452 |
L-Cysteine 13C3,15N |
L-Cysteine 13C3,15N is the 13C- and 15N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans. |
|
| DC48453 |
L-Serine-13C3,15N |
L-Serine-13C3,15N ((-)-Serine-13C3,15N) is the 13C- and 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation. |
|
| DC48454 |
L-Alanine-13C3 |
L-Alanine-13C3 (L-2-Aminopropionic acid-13C3) is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system. |
|
| DC48455 |
L-Cysteine-13C3 |
L-Cysteine-13C3 is the 13C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans. |
|
| DC48456 |
L-Aspartic acid-13C4 |
L-Aspartic acid-13C4 is the 13C-labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly. |
|
| DC48457 |
L-Threonine-13C4,15N |
L-Threonine-13C4,15N is the 13C- and 15N-labeled L-Threonine. L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed. |
|
| DC48461 |
L-Valine-13C5,15N |
L-Valine-13C5,15N is the 13C- and 15N-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid. |
|
| DC48462 |
L-Methionine-13C5,15N |
L-Methionine-13C5,15N is the 13C- and 15N-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant. |
|
| DC48463 |
L-Valine-13C5 |
L-Valine-13C5 is the 13C-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid. |
|
| DC48464 |
L-Methionine-13C5 |
L-Methionine-13C5 is the 13C-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant. |
|
| DC48465 |
L-Ornithine-1,2,3,4,5-13C5 hydrochloride |
L-Ornithine-1,2,3,4,5-13C5 hydrochloride is the 13C-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen. |
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