| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC48214 | FXIa-IN-7 | FXIa-IN-7 is a selective and orally bioavailable factor XIa inhibitor with an IC50 value of 0.4 nM. |
|
| DC48215 | Zagociguat Featured | Zagociguat is the stimulator of soluble guanylate cyclase. Zagociguat increases nitric oxide (NO) signaling leading to an increase in cyclic guanosine monophosphate production. Zagociguat has the potential for the research of noncentral nervous system (CNS) disorders. |
|
| DC48216 | NLG802 Featured | NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor. |
|
| DC48217 | IDO1-IN-11 | IDO1-IN-11 is an IDO1 inhibitor with an IC50 value of 0.6 nM. |
|
| DC48218 | IDO1-IN-12 | IDO1-IN-12 is a potent and orally available IDO1 inhibitor. |
|
| DC48219 | Safusidenib | Safusidenib is a novel IDH1 inhibitor for the treatment of IDH1-mutated tumors. |
|
| DC48220 | Mufemilast | Mufemilast is a phosphodiesterase 4 (PDE4) inhibitor. |
|
| DC48221 | Andolast | Andolast is an anti-allergic agent for the treatment of bronchial asthma, chronic obstructive pulmonary disease (COPD). Andolast inhibits dose dependently guinea-pig lung cAMP-phosphodiesterase with an IC50 of 50 mM. |
|
| DC48222 | Arofylline | Arofylline is a PDE4 inhibitor as a potential treatment for asthma. |
|
| DC48223 | ATX inhibitor 7 | ATX inhibitor 7 is a autotaxin inhibitor and shows good oral exposure. |
|
| DC48224 | Cudetaxestat | Cudetaxestat (BLD-0409) is a potent and orally active autotaxin (ATX) inhibitor. |
|
| DC48225 | PDE2A-IN-1 | PDE2A-IN-1 is a phosphodiesterase 2A (PDE2A) inhibitor with an IC50 value of 1.3 nM. |
|
| DC48226 | ONO-8430506 Featured | ONO-8430506 is an orally bioavailable and potent autotaxin (ATX)/ENPP2 inhibitor with the IC90 of 100 nM for ATX activity in mouse plasma. |
|
| DC48227 | MJ33 lithium salt | MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6. |
|
| DC48228 | (R)-Bromoenol lactone | (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipaseγ(iPLA2γ)(/b). (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM. |
|
| DC48229 | CAY10502 | CAY10502 is a potent, calcium-dependent cytosolic phospholipase A2 α (cPLA2α) inhibitor with an IC50 of 4.3 nM for isolated enzyme. CAY10502 can be used in the research of retinopathy and inflammatory diseases. |
|
| DC48230 | Sterculic acid Featured | Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with an IC50 value of 0.9 μM. |
|
| DC48231 | Idraparinux sodium | Idraparinux (sodium) is a polymethylated synthetic pentasaccharide known to interact with the antithrombin III and act as anticoagulant. |
|
| DC48232 | BAY 1217224 | BAY 1217224 is a neutral, non-prodrug Thrombin inhibitor with good oral pharmacokinetics. |
|
| DC48233 | MitoTEMPO hydrate | Mito-TEMPO is a mitochondria-targeted antioxidant that possesses superoxide and alkyl radical scavenging properties. Mito-TEMPO helps protect against oxidative damage to the mitochondria. |
|
| DC48234 | Linsidomine hydrochloride | SIN-1 (chloride) is the active metabolite of molsidomine. SIN-1 (chloride) exhibits potent vasorelaxant effect and inhibition of platelet aggregation. SIN-1 (chloride) decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion. |
|
| DC48235 | MTIC | MTIC is the active metabolite of Temozolomide (TMZ). MITC has lower bioavailability in the brain compared with TMZ, because the drug’s permeability through biological barriers and tumor cell membranes affects bioavailability. MITC exhibits low affinity to biological membrane. |
|
| DC48236 | 4β-Hydroxycholesterol | 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation. |
|
| DC48237 | Dihomo-γ-Linolenic acid methyl ester | Dihomo-γ-Linolenic acid is an n-6 polyunsaturated fatty acid that is mainly metabolized to an anti-inflammatory eicosanoid, prostaglandin (PG) E1, via the cyclooxygenase (COX) pathway. Anti-inflammatory and anti-proliferative effects. |
|
| DC48238 | 10(S),17(S)-DiHDHA | Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities. |
|
| DC48239 | 12-OxoETE | 12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via leukotriene B4 receptor or a common activation sequence. |
|
| DC48240 | Pregnanediol 3-glucuronide | Pregnanediol 3-glucuronide is the major terminal metabolite of progesterone, playing an important role in physiological processes, such as the female menstrual cycle, pregnancy (supports gestation), embryogenesis and maternal immune response of humans and other species. |
|
| DC48241 | p-Cresyl sulfate | p-Cresyl Sulfate, a major uremic toxin derived from the metabolites of tyrosine and phenylalanine through liver, existed in the blood of patients with chronic kidney disease (CKD). |
|
| DC48242 | ω-Muricholic Acid | ω-Muricholic acid (ω-MCA) is a murine-specific secondary bile acid. |
|
| DC48243 | C20 Ceramide | C20 Ceramide is a natural 20:0 ceramide that is abundant in the brain. |
|
