| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11605 | ONO-0300302 | A novel potent, slow tight binding LPA1 receptor antagonist with IC50 of 86 nM, Kd of 0.34 nM. |
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| DC22600 | HI-TOPK-032 Featured | A novel potent, specific TOPK inhibitor that has no effect on ERK1, JNK1, or p38 kinase activity. |
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| DC11553 | FT-827 | A novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain). |
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| DC23487 | AS2575959 | A novel potent, specific, orally available GPR40 agonist that influences glucose-dependent insulin secretion both in vitro pancreas β-cell-derived cells and in vivo. |
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| DC23450 | SAS-1121 | A novel potent, subtype-selective sigma 2 receptor/PGRMC1 ligand with Ki of 16.2 nM, 574-fold selectivity over sigma 1 receptors.. |
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| DC23465 | DKR-1051 | A novel potent, subtype-selective sigma 2 receptor/PGRMC1 ligand with Ki of 61 nM, 9-fold selectivity over sigma 1 receptors (Ki=556 nM). |
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| DC22370 | Meptyldinocap | A novel powdery mildew (Erysiphe necator) fungicide that shows protectant and post-infective activities. . |
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| DC22592 | Amiselimod hydrochloride (MT-1303 hydrochloride) Featured | A novel prodrug S1P receptor modulator lacking S1P3 receptor agonism to avoid bradycardia associated with fingolimod and other S1P receptor modulators. |
|
| DC11916 | FD-5180 Featured | A novel protein kinase affinity probe... |
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| DC11636 | HMCEF | A novel P-selectin inhibitor that directly binds to P-selectin. |
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| DC26112 | SLMP53-1 Featured | SLMP53-1 is a novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells. |
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| DC11917 | (R)-OR-S1 | A novel SAM-competitive, highly selective, orally bioavailable EZH1/2 dual inhibitor with IC50 of 16/50 nM, respectively. |
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| DC25071 | PDE6δ inhibitor 8 | A novel selective small molecule inhibitor of PDE6δ/KRas interaction with Kd of 358 pM.. |
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| DC23742 | Rac1-IN-6 | A novel selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 88±48 nM. |
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| DC23749 | Rac1-IN-1 | A novel selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 95±21 nM. |
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| DC21702 | SC-99 Featured | A novel selective STAT3 inhibitor that inhibits JAK2-STAT3 activation but has no effects on other transcription factors such as NF-κB, and kinases such as AKT, ERK, and c-Src. |
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| DC12010 | ML116 | A novel selective STAT3 inhibitor with IC50 of 4.2 uM, does not inhibit STAT1, STAT5, or NFkB signaling pathways (IC50>50 uM). |
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| DC11527 | Quilseconazole Featured | A novel selective, orally available fungal CYP51 (lanosterol 14-α-demethylase) inhibitor. |
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| DC12004 | NS19504 | A novel selective, small molecule large-conductance Ca(2+)-activated K(+) channel (BKCa, KCa1.1, MaxiK) positive modulator with EC50 of 11 uM. |
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| DC22660 | Tenovin-D3 | A novel selective, small-molecule inhibitor of sirtuin SITR2 with IC50 of 21.8 uM. |
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| DC11562 | Sirt2-PROTAC-1 | A novel SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM).. |
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| DC22961 | ITP-2 | A novel small molecule activator of Kv 11.1 (hERG) channel (216% over control at 3 uM for hERG1a activation). |
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| DC22982 | Aldi-6 | A novel small molecule ALDH inhibitor with IC50 of 600 nM, 800 nM and 1000 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. |
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| DC20650 | AKI603 Featured | AKI-603 is a novel small molecule Aurora A kinase inhibitor with IC50 of 12.3 nM, also inhibits Aurora B kinase activity to a less extent; disrupts normal spindle structure, and induces cell-cycle arrest; t; suppresses stem cell properties in breast cancer cells, and also suppresses the expression of self-renewal genes (β-catenin, c-Myc, Sox2, and Oct4); reduces xenograft tumor growth after intragastric administration. |
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| DC23772 | CMLD-2 | A novel small molecule disruptor of HuR-mRNA interaction with Ki of 350 nM. |
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| DC11632 | Cardioprotectant | A novel small molecule inducer of heme oxygenase-1 that protect human iPSC-derived cardiomyocytes from oxidative stress. |
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| DC25072 | Deltasonamide 1 | A novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 203 pM. |
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| DC11817 | Compound L | A novel small molecule inhibitor of the DNA repair protein Ku70/80, disrupts of Ku70/80-DNA interaction with IC50 of 3.5 uM in EMSA assay. |
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| DC21679 | Spindlactone A | A novel small molecule inhibitor of transforming acidic coiled-coil-containing protein 3 (TACC3) that selectively inhibits the nucleation of centrosome microtubules in ovarian cancer cells. |
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| DC21680 | Spindlactone B | A novel small molecule inhibitor of transforming acidic coiled-coil-containing protein 3 (TACC3) that selectively inhibits the nucleation of centrosome microtubules in ovarian cancer cells. |
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