| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC22886 | TASP 0433864 | A novel potent, selective mGluR2 positive allosteric modulator with EC50 of 199 and 206 nM for human and rat mGlu2, respectively, without exerting agonist activity. |
|
| DC20441 | MAO-B inhibitor 8f | A novel potent, selective monoamine oxidase B (MAO-B) inhibitor with IC50 of 29-56 nM. |
|
| DC20467 | mTOR inhibitor 10 | A novel potent, selective mTOR inhibitor with biochemical IC50 of 21.7 nM for mTORC1, exhibits cellular potency against mTOR with IC50 of 5 nM. |
|
| DC11985 | PSTC | A novel potent, selective Nrf2 activator with pEC50 of 7.7 (inducing of NQO1 specific enzyme activity). |
|
| DC23862 | MET inhibitor Compound 1 | A novel potent, selective orally bioavailable MET tyrosine kinase inhibitor with IC50 of <1 nM and 12 nM for unphosphorylated and phosphorylaed MET, respectively. |
|
| DC22977 | Lu AF-58027 | A novel potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively. |
|
| DC11559 | PDE5-IN-6c | A novel potent, selective PDE5 inhibitor with IC50 of 0.056 nM for PDE5A1. |
|
| DC11969 | (S)-C33 | A novel potent, selective PDE9A inhibitor with IC50 of 11 nM, >45-fold selectivity over other PDE isoforms. |
|
| DC11585 | MZ-242 | A novel potent, selective Sirt2 inhibitor with IC50 of 0.118 uM. |
|
| DC11587 | SirReal1 Featured | A novel potent, selective Sirt2 inhibitor with IC50 of 3.745 uM. |
|
| DC11867 | TBK1 PROTAC 1 | A novel potent, selective TBK1 PROTAC with DC50 of 12 nM, selectively degrades TBK1 with excellent selectivity against a related kinase IKKε. |
|
| DC21458 | (S)-PBMC | A novel potent, selective TRPM8 antagonist with IC50 of 15.6 nM (hTRPM8). |
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| DC20951 | DFL 23448 | A novel potent, selective TRPM8 channel antagonist with IC50 of 10 and 21 nM in hTRPM8 HEK293 cells activated by Cooling Agent 10 or cold. |
|
| DC21747 | tBPC | A novel potent, selective Y4R positive allosteric modulator (EC50=5.1 uM) that potentiates Y4R activation in G-protein signaling and arrestin3 recruitment experiments. |
|
| DC22700 | DETQ | A novel potent, selective, allosteric and orally active dopamine D1 receptor potentiator with Kb of 26 nM. |
|
| DC11777 | PDM-631 | A novel potent, selective, brain-penetrable and orally active PDE2A inhibitor with IC50 of 1.5 and 4.2 nM for human and rat PDE2A, respectively. |
|
| DC22857 | Pyr-1 | A novel potent, selective, cell permeable and ATP competitive LIMK inhibitor. |
|
| DC23672 | Gemigliptin Featured | A novel potent, selective, competitive and orally active DPP4 inhibitor with potential for the treatment of type 2 diabetes. |
|
| DC20685 | AS2795440 | A novel potent, selective, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=2 nM). |
|
| DC20782 | BI 689648 | A novel potent, selective, orally active aldosterone synthase inhibitor with IC50 of 2 nM, displays 150-fold selectivity over related cortisol synthase. |
|
| DC11730 | GNE-207 | A novel potent, selective, orally active CBP/p300 bromodomain with IC50 of 1.0 nM. |
|
| DC22673 | SCH 486757 | A novel potent, selective, orally active nociceptin/orphanin FQ peptide (NOP, ORL1) receptor agonist with Ki of 4.6 nM, with high selectiivity over classical opioid receptors. |
|
| DC21441 | ONO-2952 | A novel potent, selective, orally active translocator protein 18 kDa (TSPO/PBR) antagonist with Ki of 0.33-9.3 nM for both rat and human TSPO. |
|
| DC11536 | Imigliptin dihydrochloride | A novel potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM. |
|
| DC11631 | INCB040093 | A novel potent, selective, orally available PI3Kδ inhibitor with IC50 of 31 nM. |
|
| DC22740 | RO 5126946 | A novel potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM. |
|
| DC20690 | ASP 2905 Featured | A novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM. |
|
| DC11547 | LY-2562175 Featured | LY2562175 is a potent and selective FXR agonist, with an EC50 of 193 nM. |
|
| DC21522 | Balixafortide(POL6326) Featured | Balixafortide(POL 6326) is a novel potent, selective, peptidic CXCR4 antagonist that interferes with the tumor-protective microenvironment and sensitizes tumor cells to chemotherapy. |
|
| DC11826 | ASP-6537 | A novel potent, selective, reversible cyclooxygenase-1 (COX-1) inhibitor with IC50 of 4.9 nM. |
|
