Cat. No. | Product name | CAS No. |
DC9252 |
BMS-687453
Featured
BMS687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) α agonist, with an EC50 of 10 nM for human PPARα and ∼410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays. |
1000998-59-3 |
DC9700 |
BMS-707035
Featured
BMS-707035 is a potent, specific, and reversible HIV-I integrase (IN) inhibitor that blocks HIV IN strand transfer activity. |
729607-74-3 |
DC3114 |
Avagacestat (BMS-708163)
Featured
BMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectively. |
1146699-66-2 |
DC3126 |
BMS754807
Featured
BMS-754807 is a potent and reversible inhibitor of IGF-1R/IR family kinases, inhibits IGF-1R, IR, Met, TrkA and TrkB with IC50 of 1.8 nM, 1.7 nM, 5.6 nM, 7.4 nM and 4.1 nM, respectively. |
1001350-96-4 |
DC9861 |
BMS-779788(XL-652)
Featured
BMS-779788(XL652) is a novel small-molecule modulator of the Liver X Receptor (LXR), a nuclear hormone receptor implicated in a variety of cardiovascular and metabolic disorders. |
918348-67-1 |
DC9638 |
BMS-794833
BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50 of 1.7/15 nM; also inhibits Ron, Axl and Flt3 with IC50 of <3 nM; a prodrug of BMS-817378. |
1174046-72-0 |
DC11862 |
BMS-906024
BMS-906024 is a highly potent, selective inhibitor of γ-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9 nM, respectively. |
1401066-79-2 |
DC4175 |
BMS-911543
Featured
BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, approximately 350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. |
1271022-90-2 |
DC10459 |
BMS-986020
Featured
BMS-986020 is an LPA1 antagonist. |
1257213-50-5 |
DC11923 |
BMS-986120
Featured
BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4. |
1478712-37-6 |
DC11819 |
BMS-986142
Featured
BMS-986142 is a potent, selective, and reversible BTK (Bruton’s tyrosine kinase) inhibitor (BTK IC₅₀ = 0.5nM; human WB IC₅₀ = 90 nM). |
1643368-58-4 |
DC10609 |
BMS-986158
Featured
BMS-986158 is an inhibitor of the bromodomain and extra-terminal (BET) proteins. |
1800340-40-2 |
DC12030 |
BMS-986195
Featured
BMS-986195 is a potent, covalent, irreversible inhibitor of Bruton’s tyrosine kinase (BTK). |
1912445-55-6 |
DC10131 |
BMS-986205(Linrodostat)
Featured
BMS-986205 is an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic activity, alone and in combination with nivolumab in advanced cancers in a phase 1/2a trial |
1923833-60-6 |
DC5077 |
Boceprevir(EBP 520; SCH 503034 )
Featured
Boceprevir(EBP 520; SCH 503034 ) is useful for Anti HCV. |
394730-60-0 |
DC1027 |
Bortezomib (Velcade,MG-341,PS-341)
Featured
Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM. |
179324-69-7 |
DC8883 |
BP897
Featured
BP897 is a partially selective D3 dopamine receptor agonist. |
314776-92-6 |
DC8392 |
BQ-123
Featured
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2. |
136553-81-6 |
DC7097 |
Cebranopadol(GRT-6005)
Featured
branopadol(GRT-6005) is a novel first in class compounds with potent agonist activity on ORL-1 (opioid receptor like -1) and the well established mu opioid receptor. |
863513-91-1 |
DC2019 |
Brivanib (bms-540215)
Featured
Brivanib is an ATP-competitive inhibitor against human VEGFR2 and FGFR with IC50 of 25 nM and 148 nM, respectively. |
649735-46-6 |
DC11038 |
Bryostatin 1
Featured
Bryostatin 1 (NSC 339555) is a macrocyclic lactone derived from a marine invertebrate, fuctions as an activator of PKC with high binding affinity (Ki=1.35 nM). |
83314-01-6 |
DC7378 |
BSI-201
BSI-201 (Iniparib; NSC-746045) is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC). |
160003-66-7 |