Cat. No. | Product name | CAS No. |
DC10335 |
BGB-3111
BGB-3111 is a potent, selective and orally available Bruton's tyrosine kinase (Btk) inhibitor. |
1633350-06-7 |
DC5194 |
NVP-BGJ398(Infigratinib)
Featured
BGJ398 (NVP-BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2. |
872511-34-7 |
DC8571 |
BGP-15
Featured
BGP-15 is a PARP inhibitor and insulin sensitizer. |
66611-37-8 |
DC11389 |
BI 409306
Featured
BI 409306 is an inhibitor of phosphodisterase 9A(PDE9A). |
1189767-28-9 |
DC11842 |
BI 135585
BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively. |
1114561-85-1 |
DC7083 |
Bi 2536
Featured
BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM, BI2536 shows 4- and 11-fold greater selectivity against Plk2 and Plk3; BI2536 also is a BRD4 inhibitor(IC50= 25 nM). |
755038-02-9 |
DC8401 |
BI-847325
Featured
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1. |
1207293-36-4 |
DC10404 |
BIA 10-2474
Featured
BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC50 values of 50 to 70mg/kg in various rat brain regions. |
1233855-46-3 |
DCAPI1112 |
BIBR 953(Dabigatran)
Featured
BIBR 953 (Dabigatran, Pradaxa) is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. |
211914-51-1 |
DC1010 |
BIBR-1048 (Dabigatran etexilate)
Featured
BIBR-1048 (Dabigatran) is an anticoagulant from the class of the direct thrombin inhibitors. |
211915-06-9 |
DC10890 |
Bictegravir
Featured
Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM. |
1611493-60-7 |
DC7086 |
BIIB021(CNF2024)
Featured
BIIB021(CNF2024) is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively. |
848695-25-0 |
DC8882 |
Bitopertin
Bitopertin, also known as RG1678, is a potent and selective inhibitor of GlyT1 with an EC50 of 30nM. |
845614-11-1 |
DC5154 |
BKM120 (NVP-BKM120, Buparlisib)
Featured
BKM120 is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. |
944396-07-0 |
DC4196 |
Bleomycin Sulfate
Featured
Bleomycin sulfate (Blenoxane) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells. |
9041-93-4 |
DC10530 |
BLU-285 (Avapritinib)
Featured
BLU-285 is a potent and selective exon 17 mutant KIT kinase inhibitor with IC50 of 0.27 nM for KIT D816V. |
1703793-34-3 |
DC10092 |
BLU554(Fisogatinib)
Featured
BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor. |
1707289-21-1 |
DC11479 |
BLU-667 (Pralsetinib)
Featured
BLU-667 (Pralsetinib) is a highly potent, selective, next generation RET inhibitor with IC50 of 0.3-0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion. |
2097132-94-8 |
DC8280 |
BLU-9931
Featured
BLU9931 is the first selective small molecule inhibitor of FGFR4 with IC50 of 3 nM; less potent for FGFR1/2/3(IC50> 150 nM). |
1538604-68-0 |
DC8103 |
BLZ-945
Featured
BLZ945 is a highly selective and brain-penetrant inhibitor of CSF1R with IC50 of 1 nM; >3200-fold higher than its affinity for other kinases. |
953769-46-5 |
DC11761 |
BMS-816336
A novel potent, selective, orally active human 11β-HSD1 inhibitor with IC50 of 3.0 nM. |
1009583-20-3 |
DC3105 |
BMS-599626 (AC480)
Featured
BMS-599626 (AC480) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, respectively. |
714971-09-2 |