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Home > Inhibitors & Agonists > Epigenetics > Sirtuin

3-TYP

  Cat. No.:  DC10616   Featured
Chemical Structure
120241-79-4
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More than 5000 active chemicals with high quality for research!
Field of application
3-TYP is a selective SIRT3 inhibitor.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 120241-79-4
Chemical Name: 3-(1H-1,2,3-Triazol-4-yl)pyridine
Synonyms: Pyridine,3-(1H-1,2,3-triazol-5-yl)-;3-(1H-1,2,3-Triazol-4-yl)pyridine;3-TYP;Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI);Pyridine(3-TYP);3-(1H-1,2,3-triazol-5-yl)pyridine;3-(1,2,3-triazol-4-yl)pyridine;3-(1H-1,2,3-triazol-4-yl) pyridine;Pyridine,3-(1H-1,2,3-triazol-4-yl)- (9CI);3-(2H-triazol-4-yl)pyridine;pyridin-3-yl-triazole;BDBM17471;VYXFEFOIYPNBFK-UHFFFAOYSA-N;BCP25686;4-(3-Pyridyl)-1,2,3-triazole;4-(3-Pyridinyl)-1H-1,2,3-triazole;AK204058;3-(2
SMILES: N1=C(C([H])=NN1[H])C1=C([H])N=C([H])C([H])=C1[H]
Formula: C7H6N4
M.Wt: 146.1493
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: 3-TYP is a selective SIRT3 inhibitor, with an IC50 of 16 nM, more potent over SIRT1 (IC50=88 nM), SIRT2 (IC50=92 nM).
In Vivo: 3-TYP (50 mg/kg, i.p.) does not significantly influence the LVEF, LVFS, infarct size, serum LDH levels, apoptosis, and oxidative stress compared with those of the Sham group. Moreover, 3-TYP has little effect on gp91phox, Nrf2, NQO 1, Bax, Bcl-2, Caspase-3, and cleaved Caspase-3 expression levels, compared with the Sham group. 3-TYP significantly decreases SIRT3 activity and increases the acetylation of SOD2 compared with that in the control group, without influencing SIRT3 expression. 3-TYP attenuates the cardioprotective effects of melatonin by decreasing the LVEF and LVFS after 24 hour of reperfusion. 3-TYP also increases the infarct size, serum LDH levels, and apoptotic ratio compared with those in the IR+Mel group[2].
In Vitro: 3-TYP inhibits melatonin-enhanced SIRT3 activity but does not affect SIRT3 protein expression. 3-TYP pretreatment reverses the protective effects of melatonin on cadmium (Cd)-induced mitochondrial-derived O2•− production and autophagic cell death. 3-TYP significantly attenuates melatonin-induced increases in deacetylated-SOD2 expression and SOD2 activity in HepG2 cells exposed to Cd[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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