Molecular Glues

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Cat. No.	Product Name	Field of Application
DCW-009	Schisandrin C Featured	Schisandrin C (Schizandrin-C) is a phytochemical lignan derived from Schizandra chinensis, known for its diverse biological activities, including anticancer, anti-inflammatory, and antioxidant effects. Functioning as a molecular glue, Schisandrin C holds potential for research in cancer, Alzheimer’s disease, and liver diseases. It also induces cell apoptosis.
DC6311	Pomalidomide Featured	Pomalidomide, a third-generation immunomodulatory compound, functions as a molecular glue by binding to the E3 ligase cereblon, leading to the targeted degradation of critical Ikaros transcription factors.
DC20779	BI-3802 Featured	BI-3802 (BI3802) is a highly potent and effective BCL6 degrader that disrupts the interaction between the BTB/POZ domain of BCL6 and its co-repressors in vitro, achieving an IC50 of less than 3 nM.
DC10146	Avadomide（CC 122） Featured	Avadomide is an orally bioavailable cereblon modulator that regulates cereblon E3 ligase activity, inhibits the NF-κB pathway, and induces cell cycle arrest at the G1 phase, leading to apoptosis in pancreatic ductal adenocarcinoma (PDAC) cells. It demonstrates significant antitumor and immunomodulatory effects.
DC11588	CC-885 Featured	CC-885 (CC 885, CC885) is a novel modulator of the E3 ligase cereblon (CRBN) that exhibits strong anti-tumor activity by promoting the degradation of the protein GSPT1.
DC4115	Cyclosporin A Featured	Cyclosporin A (Cyclosporine A) is a potent immunosuppressive agent commonly administered after allogeneic organ transplants to suppress immune system activity and prevent rejection.
DC10784	E7820 Featured	E7820 is an angiogenesis inhibitor that exerts its effects by targeting integrin α2, a cell adhesion molecule prominently expressed on endothelial cells.
DC10174	Iberdomide Featured	Iberdomide (CC-220) is a cereblon modulator currently undergoing clinical development for the treatment of systemic lupus erythematosus. It demonstrates potent activity with an IC50 of 60 nM in a TR-FRET cereblon binding assay.
DC20984	Indisulam Featured	Indisulam (E7070) is a potent sulfonamide-based cell-cycle inhibitor with notable antiproliferative effects. It induces a reduction in the S phase fraction while promoting G1 and/or G2 phase accumulation in various cancer cell lines.
DCAPI1502	Lenalidomide Featured	Lenalidomide, a derivative of thalidomide, is recognized for its ability to inhibit TNF-α secretion and exhibit significant immunomodulatory effects.
DC20251	NRX-103094 Featured	NRX-103094 is a potent enhancer of the interaction between β-catenin and its cognate E3 ligase, SCFβ-TrCP. It significantly strengthens the binding of the pSer33/Ser37 β-catenin peptide to β-TrCP, exhibiting an EC50 of 62 nM and a Kd of 0.6 nM.
DC20252	NRX-252114 Featured	NRX-252114 is a potent enhancer of the interaction between β-catenin and its cognate E3 ligase, SCFβ-TrCP. It significantly strengthens the binding of the pSer33/S37A β-catenin peptide to β-TrCP, exhibiting an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 also induces the degradation of mutant β-catenin.
DC20253	NRX-252262 Featured	NRX-252262 is a powerful enhancer of the interaction between β-Catenin and its cognate E3 ligase, SCFβ-TrCP. It effectively induces the degradation of mutant β-catenin, demonstrating an EC50 of 3.8 nM.
DC7312	Tasisulam(LY573636) Featured	Tasisulam is an anticancer agent that triggers apoptosis through the intrinsic pathway, leading to cytochrome c release and caspase-dependent cell death. It also inhibits mitotic progression and promotes vascular normalization.
DC9009	Thalidomide Featured	Thalidomide has the ability to directly suppress angiogenesis triggered by bFGF or VEGF in vivo.
DC28185	Chloroquinoxaline sulfonamide Featured	Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analog of sulfaquinoxaline, acts as a topoisomerase II alpha/beta poison. It is utilized to manage coccidiosis in poultry, rabbits, sheep, and cattle, while also demonstrating antitumor activity.
DC28693	CC-90009 Featured	CC-90009 is a cereblon modulator that selectively binds to CRBN, influencing the activity of the ubiquitin E3 ligase complex. This interaction triggers the ubiquitination and subsequent proteasome-mediated degradation of specific transcription factors, such as Ikaros (IKZF1) and Aiolos (IKZF3), which act as transcriptional repressors in T-cells. By reducing the levels of these factors, CC-90009 modulates immune system activity, potentially leading to the activation of T-lymphocytes.
DC28972	(S)-Thalidomide Featured	(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-enantiomer of Thalidomide, known for its immunomodulatory, anti-inflammatory, antiangiogenic, and pro-apoptotic properties. It induces teratogenic effects through its binding to cereblon (CRBN).
DC29000	(R)-CR8 trihydrochloride Featured	(R)-CR8 trihydrochloride (CR8 trihydrochloride), a second-generation derivative of Roscovitine, is a highly potent inhibitor of CDK1/2/5/7/9. It exhibits inhibitory activity against CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM), and CK1δ/ε (0.4 μM). (R)-CR8 trihydrochloride induces apoptosis and demonstrates neuroprotective properties.
DC39084	Mezigdomide(CC-92480) Featured	Mezigdomide is a cereblon E3 ubiquitin ligase modulator with immunomodulatory and antineoplastic properties. By specifically binding to cereblon (CRBN), it alters the activity of the ubiquitin E3 ligase complex, leading to the ubiquitination and subsequent proteasome-mediated degradation of specific transcription factors, including those that act as transcriptional repressors in T cells. This process modulates immune system activity, such as T lymphocyte activation, and suppresses the function of proteins critical for the proliferation of certain cancer cells.
DC40405	CCT369260 Featured	CCT369260 (compound 1) is an orally active inhibitor of B-cell lymphoma 6 (BCL6) with significant anti-tumor activity. It demonstrates an IC50 value of 520 nM.
DC55050	SJ6986 Featured	SJ6986 is a highly potent, selective, and orally bioavailable degrader of GSPT1/2, with a DC50 of 2.1 nM. It exhibits strong antiproliferative effects in MV4-11 and MHH-CALL-4 cell lines, showing IC50 values of 1.5 nM and 0.4 nM, respectively.
DC47521	ALV2 Featured	ALV2 is a potent and selective degrader of Helios, a zinc-finger transcription factor crucial for maintaining a stable regulatory T-cell (Treg) phenotype in inflammatory tumor microenvironments. ALV2 binds to CRBN with an IC50 of 0.57 μM, demonstrating its specificity and efficacy.
DC47881	TMX-4116 Featured	TMX-4116 is a potent degrader of casein kinase 1α (CK1α), demonstrating strong degradation activity with DC50 values below 200 nM in MOLT4, Jurkat, and MM.1S cell lines. It holds significant potential for research applications in multiple myeloma.
DC47882	TMX-4113 Featured	TMX-4113 is a degrader targeting phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α). It is a valuable tool for cancer research.
DC47883	TMX-4100 Featured	TMX-4100 is a selective degrader of phosphodiesterase 6D (PDE6D), exhibiting high degradation efficiency with DC50 values below 200 nM in MOLT4, Jurkat, and MM.1S cells. It is a promising compound for research in multiple myeloma.
DC47989	FPFT-2216 Featured	FPFT-2216 is a "molecular glue" compound that induces the degradation of phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), and casein kinase 1α (CK1α). It holds potential for research in cancer and inflammatory diseases.
DC49255	Biotin-Thalidomide Featured	Biotin-Thalidomide serves as a cereblon affinity probe, widely used in PROTAC and targeted protein degradation research.
DC49931	NVP-DKY709 Featured	NVP-DKY709 is a powerful IKZF2 inhibitor with significant potential for cancer therapy.
DC50173	dCeMM4 Featured	dCeMM4 (Compound 5) is a molecular glue degrader that facilitates the ubiquitination and degradation of cyclin K. It achieves this by promoting an interaction between the CDK12-cyclin K complex and the CRL4B ligase complex.

Molecular Glues

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