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Home > Inhibitors & Agonists > GPCR > 5-HT Receptor

8-OH-DPAT

  Cat. No.:  DC10537   Featured
Chemical Structure
78950-78-4
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More than 5000 active chemicals with high quality for research!
Field of application
8-OH-DPAT is a research chemical of the aminotetralin chemical class and has been widely used to study the function of the 5-HT1A receptor.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 78950-78-4
Chemical Name: 1-Naphthalenol,7-(dipropylamino)-5,6,7,8-tetrahydro-
Synonyms: 1-Naphthalenol,7-(dipropylamino)-5,6,7,8-tetrahydro-;8-HYDROXY-DPAT HYDROBROMIDE;S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT;(+/-)-2-dipr;(+/-)-2-dirpopylamino-7-hydroxy-1,2,3,4-tetrahydronaphthalene;(+/-)-7-OH-DPAT HYDROBROMIDE;(2R)-(+)-8-hydroxy-2-(di-n-propylamino)tetralin;[123I]-(+/-)-7-OH-DPAT;[3H]-(+/-)-8-OH-DPAT;-]-7-OH-DPAT HYDROBROMIDE;7-Hydroxy-DAPT;7-HYDROXY-DPAT HYDROBROMIDE;7-OH-DPAT;8-hydroxy-2-(di-n-propylamino)tetralin;8-hydroxy-2-(di-N-propylamino)-tetralin;8-OH-2-(di-n-propylamino)-1,2,3,4-tetrahydronaphthalene;R(+)-7-OH-DPAT;S(−)-8-OH-DPAT HBr
SMILES: OC1=C2CC(N(CCC)CCC)CCC2=CC=C1
Formula: C16H25NO
M.Wt: 247.3758
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: 8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5).
Target: pIC50: 8.19 (5-HT1A)[1] Ki: 466 nM (5-HT7)[2]
In Vivo: 8-OH-DPAT (1 mg/kg) normalizes hypolocomotion, significantly increases wakefulness and reduces the duration of REM sleep without effect on the duration of non-REM sleep in the dark period in orexin knockout (KO) mice. 8-OH-DPAT shows no obvious effect on wakefulness or the duration of either REM sleep or non-REM sleep in WT mice. 8-OH-DPAT (1 mg/kg, s.c.) activates 5-HT1A receptor in orexin knockout mice[3].
In Vitro: 8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A; weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5)[1]. 8-OH-DPAT has high affinity at 5-HT7 with a Ki of 466 nM, and does not bind to 5-HT6 or 5-HT4[2].
Animal Administration: 8-OH-DPAT (1 mg/kg) normalizes hypolocomotion, significantly increases wakefulness and reduces the duration of REM sleep without effect on the duration of non-REM sleep in the dark period in orexin knockout (KO) mice. 8-OH-DPAT shows no obvious effect on wakefulness or the duration of either REM sleep or non-REM sleep in WT mice. 8-OH-DPAT (1 mg/kg, s.c.) activates 5-HT1A receptor in orexin knockout mice[3].
References: [1]. DEREK N. MIDDLEMISS, et al. 8-HYDROXY-2-(DI-n-PROPYLAMINO)-TETRALIN DISCRIMINATES BETWEEN SUBTYPES OF [2]. Bard JA, et al. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J Biol Chem. 1993 Nov 5;268(31):23422-6. [3]. Mori T, et al. Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT. Psychopharmacology (Berl). 2016 Jun;233(12):2343-53.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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