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BF-227(E/Z)

  Cat. No.:  DC12131   Featured
Chemical Structure
845647-80-5
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More than 5000 active chemicals with high quality for research!
Field of application
BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 845647-80-5
Chemical Name: BF-227,BF227,BF 227
Synonyms: BF-227,BF227,BF 227
SMILES: CN(C)C1=NC=C(S1)/C=C/C2=NC3=CC=C(OCCF)C=C3O2
Formula: C16H16FN3O2S
M.Wt: 333.38
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Kudo Y, et al. Development of amyloid imaging PET probes for an early diagnosis of Alzheimer's disease. Minim Invasive Ther Allied Technol. 2006;15(4):209-13. [2]. Furukawa K, et al. Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227: comparison to FDG-PET. J Neurol. 2010 May;257(5):721-7.
Description: BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils.
Target: Ki: 4.3 nM (Aβ1-42)[1].
In Vitro: BF-227 has a high binding affinity for Aβ1-42 fibrils. The Ki value for Aβ1-42 fibrils in competitive binding assay using [125I]BF-180 is 4.3±1.3 nM in BF-227 (Kd value of [125I]BF-180: 10.8±1.5 nM)[1]. [11C]BF-227 is a PET tracer. The AUC for BF-227 (0.994) is much higher than that for FDG (0.839), indicating that BF-227 is more sensitive as well as more specific than FDG in diagnosing AD[2].
References: [1]. Kudo Y, et al. Development of amyloid imaging PET probes for an early diagnosis of Alzheimer's disease. Minim Invasive Ther Allied Technol. 2006;15(4):209-13. [2]. Furukawa K, et al. Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227: comparison to FDG-PET. J Neurol. 2010 May;257(5):721-7.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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