AFN-1252(Debio 1452)|cas 620175-39-5|DC Chemicals

Cas No.:	620175-39-5
Chemical Name:	Afn-1252
Synonyms:	Debio 1452
SMILES:	O1C2=C([H])C([H])=C([H])C([H])=C2C(C([H])([H])[H])=C1C([H])([H])N(C([H])([H])[H])C(/C(/[H])=C(\[H])/C1C([H])=NC2=C(C=1[H])C([H])([H])C([H])([H])C(N2[H])=O)=O
Formula:	C₂₂H₂₁N₃O₃
M.Wt:	375.42
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AFN-1252(Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibited all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ≤0.12 μg/ml. IC50 value:Target: Antibiotic agentAFN-1252 was inactive (MIC90, >4 μg/ml) against clinical isolates of Streptococcus pneumoniae, beta-hemolytic streptococci, Enterococcus spp., Enterobacteriaceae, nonfermentative gram-negative bacilli, and Moraxella catarrhalis. These data support the continued development of AFN-1252 for the treatment of patients with resistant staphylococcal infections.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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