AG-024322(AG024322)|CDK inhibitor|DC Chemicals

Cas No.:	837364-57-5
Chemical Name:	N-[[5-[(3E)-3-(4,6-difluorobenzimidazol-2-ylidene)-1,2-dihydroindazol-5-yl]-4-methylpyridin-3-yl]methyl]ethanamine
Synonyms:	AG-024322; AG24322; AG 024322.
SMILES:	CC1=C(CNCC)C=NC=C1C2=CC3=C(NN=C3C4=NC5=CC(F)=CC(F)=C5N4)C=C2
Formula:	C₂₃H₂₀F₂N₆
M.Wt:	418.441906
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

In vitro: Ki = 1–3 nM (CDK1, CDK2 and CDK4)141; displayed CDK selectivity over non-CDKs141; arrested multiple stages of the cell cycle and induced apoptosis in various human tumour cell lines (IC50 = 30–200 nM)141 bulletDisplayed dose-dependent antitumour activity in mice bearing human tumour xenografts142 bulletIntravenous toxicity in cynomolgus monkey included bone marrow hypocellularity, lymphoid depletion and vascular irritation (at doses greater than or equal to 6 mg per kg); the no-adverse-effect dose was 2 mg per kg143For the detailed information of AG-024322, the solubility of AG-024322 in water, the solubility of AG-024322 in DMSO, the solubility of AG-024322 in PBS buffer, the animal experiment (test) of AG-024322, the cell expriment (test) of AG-024322, the in vivo, in vitro and clinical trial test of AG-024322, the EC50, IC50,and Affinity of AG-024322, Please contact DC Chemicals.

MSDS

COA

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2018-0101

Cat. No.	Product name	Field of application
DC47707	CDK/HDAC-IN-1	CDK/HDAC-IN-1 shows remarkable CDK2/4/6 and HDAC6 inhibitory activity of IC50 = 60.9 ± 2.9, 276 ± 22.3, 27.2 ± 4.2, and 128.6 ± 0.4 nM, respectively.
DC47706	CDK2-IN-7	CDK2-IN-7 is a CDK2 inhibitor for treating cancer (IC50 < 50 nM).
DC47705	JH-XVI-178	JH-XVI-178 is a highly potent and selective inhibitor of CDK8/19 that displays low clearance and moderate oral pharmacokinetic properties.
DC47704	CDK9-IN-12	CDK9-IN-12 displays the optimal CDK9 inhibitory activity with an IC50 value of 5.41 nM.
DC47236	Cirtuvivint	Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor. Cirtuvivint can be used for solid tumors research.
DC47205	Eltenac	Eltenac, a non-steroidal anti-inflammatory drug (NSAID), is a COX inhibitor. Eltenac shows IC50 of 0.03 μM for both COX-1 and COX-2 in isolated human whole blood.
DC47130	CDK5-IN-1	CDK5-IN-1, a potent CDK5 inhibitor, is against CDK5 activity less than 10 nM. CDK5-IN-1 is used for kidney diseases research.
DC47109	Cimpuciclib	Cimpuciclib is a cyclin-dependent kinase(CDK) inhibitor and antineoplastic.
DC47043	Ocarocoxib	Ocarocoxib, a potent COX-2 (cyclooxygenase-2) inhibitor, is a non-steroidal anti-inflammatory for veterinary use.
DC46945	Avotaciclib	Avotaciclib (BEY1107) is an orally active cyclin dependent kinase 1 (CDK1) inhibitor. Avotaciclib can be used for the research of cancer.