AVN944|cas 501345-02-4|DC Chemicals

Cas No.:	297730-17-7
Chemical Name:	VX 944, AVN-944;
Synonyms:	VX 944, AVN-944;
SMILES:	C[C@@H](C1C=CC=C(NC(NC2=CC=C(C3OC=NC=3)C(OC)=C2)=O)C=1)NC(O[C@H](CC)CC#N)=O
Formula:	C₂₄H₂₅N₅O₅
M.Wt:	463.4858
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AVN-944(VX-944) is a selective, noncompetitive inhibitor of the enzyme directed against human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2

In Vitro:

AVN-944 strikingly inhibit RNA synthesis within 2 h of exposure. Depletion of guanine nucleotides by MPA and AVN-944 also causes an early and near-complete reduction in levels of the 45S precursor rRNA synthesis and the concomitant translocation of nucleolar proteins including nucleolin, nucleophosmin, and nucleostemin from the nucleolus to the nucleoplasm [2]. AVN944 induced caspase-dependentand caspase-independent cell death in LNCaP, CWR22Rv1, and DU145 cells. AVN944 induced expression of p53-target proteins Bok, Bax and Noxa in androgen-responsive cell lines and suppressed expression of survivin in prostate cancer cells regardless of their androgen sensitivity. AVN944 also induced differentiation of androgen-independent prostate cancer cells as indicated by morphological changes and increased expression of genes coding for prostasomal proteins, keratins and other proteins, including tumor suppressor genes MIG-6 and NDRG1. AVN944-differentiated androgen-independent DU145 and PC-3 cells are sensitized to TRAIL-induced apoptosis as demonstrated by induction of caspases and PARP cleavage [3].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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