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AZM475271

  Cat. No.:  DC9627   Featured
Chemical Structure
476159-98-5
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More than 5000 active chemicals with high quality for research!
Field of application
AZM475271 is a potent and selective Src kinase inhibitor with IC50 of 5 nM; no inhibitory activity on Flt3, KDR, Tie-2.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 476159-98-5
Chemical Name: AZM-475271;M475271;M-475271
Synonyms: AZM-475271;M475271;M-475271
SMILES: CN1CCC(COC2=CC3=NC=NC(NC4=CC(OC)=CC=C4Cl)=C3C=C2OC)CC1
Formula: C23H27ClN4O3
M.Wt: 442.9385
Description: AZM475271 is a potent and selective Src kinase inhibitor with IC50 of 5 nM; no inhibitory activity on Flt3, KDR, Tie-2.
In Vivo: Tumors appeared to be palpable at day 14 after tumor cell injection in all animals except mice treated with both AZM475271 and gemcitabine, in which the earliest possible palpation of the tumors was at day 17 after tumor cell injection. Treatment with gemcitabine or AZM475271 alone did not significantly change animal weight [2].
In Vitro: AZM475271 demonstrated strong dose-dependent inhibition of Src tyrosine kinase activity in the L3.6pl human pancreatic carcinoma cell line. Maximum reduction of Src kinase activity was observed after incubation for 4 hours with ≥5 μmol/L. The IC50 concentration of AZM475271 to inhibit the phosphorylation of c-src, lck, and c-yes was 0.01, 0.03, and 0.08 μmol/L, respectively, in comparison with an IC50 of 0.7 μmol/L AZM475271 to inhibit KDR [2].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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