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Azido-PEG8-NHS ester

  Cat. No.:  DC28623   Featured
Chemical Structure
1204834-00-3
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Field of application
Azido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1204834-00-3
Chemical Name: Azido-PEG8-NHS ester
Synonyms: Azido-PEG8-NHS ester;Azido-dPEG?8-NHS ester;Azido-dPEG(R)8-NHS ester;(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
SMILES: O(C(C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N=[N+]=[N-])=O)N1C(C([H])([H])C([H])([H])C1=O)=O
Formula: C23N4O12H40
M.Wt: 564.5833
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Azido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Target: PEGs Alkyl/ether Cleavable
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References: [1]. Mahendra Persaud Deonarain, et al. Biological materials and uses thereof. WO2016046574A1. [2]. Rong Yuan, et al. Viruslike Element-Tagged Nanoparticle Inductively Coupled Plasma Mass Spectrometry Signal Multiplier: Membrane Biomarker Mediated Cell Counting. Analytical Chemistry (Washington, DC, United States) (2019), 91(8), 4948-4952.
MSDS
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MSDS_12675_DC28623_1204834-00-3
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Cat. No. Product name Field of application
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