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Azido-acetal linker is stable at physiological pH (7.4) but rapidly hydrolyzes in the acidic environment of endosomes useful as a fragment of lipid synthesis.
Oleyl bromide ((Z)-1-Bromooctadec-9-ene) is a hydrophobic compound that can carry out ring-opening reaction through a process called "encapsulation". Oleyl bromine can also be used as the starting material in the synthesis of oleylphosphonates.
This study developed CRD-PEG-T7, a prostate cancer-targeting gene delivery system featuring a disulfide-crosslinked arginine-aspartic acid peptide vector modified with T7 targeting ligands for selective pDNA delivery in PCa gene therapy.