Betahistine Dihydrochloride|cas 5579-84-0|DC Chemicals

Cas No.:	5579-84-0
SMILES:	Cl.Cl.CNCCC1C=CC=CN=1
Formula:	C₈H₁₄Cl₂N₂
M.Wt:	209.12
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Betahistine Dihydrochloride is a histamine H3 receptors inhibitor used as an antivertigo drug.Betahistine, a structural analogue of histamine with weak histamine H(1) receptor agonist and more potent H(3) receptor antagonist properties. Betahistine acts centrally by enhancing histamine synthesis within tuberomammillary nuclei of the posterior hypothalamus and histamine release within vestibular nuclei through antagonism of H(3) autoreceptors. Therapeutic effects of betahistine in vestibular disorders result from its antagonist properties at histamine H(3) receptors (H(3)Rs). On inhibition of cAMP formation and [(3)H]arachidonic acid release, betahistine behaved as a nanomolar inverse agonist and a micromolar agonist. After acute oral administration, Betahistine increased t-MeHA levels with an ED(50) of 2 mg/kg, a rightward shift probably caused by almost complete first-pass metabolism. Therapeutic effects of betahistine result from an enhancement of histamine neuron activity induced by inverse agonism at H(3) autoreceptors.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
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DCAPI1584	Roxatidine Acetate Hydrochloride	Roxatidine Acetate Hydrochloride is a histamine H2-receptor antagonist used in ulcer treatment. This compound has been found to inhibit platelet function in vitro.
DC9083	Pheniramine Maleate	Pheniramine Maleate ia an antihistamine and vasoconstrictor.
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DC9132	Ketotifen fumarate	Ketotifen (fumarate) is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks.
DC9073	Famotidine	Famotidine is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
DC9109	Doxylamine succinate	Doxylamine is a first generation antihistamine; can be used by itself as a short-term sedative and in combination with other drugs to provide night-time allergy and cold relief.
DC9057	Desloratadine	Desloratadine(Sch34117) is a potent antagonist for human histamine H1 receptor used to treat allergies.
DCAPI1536	Cyproheptadine Hydrochloride	Cyproheptadine hydrochloride is a migraine prophylactic and Non-selective SR-2A (5HT2) antagonist. Cyproheptadine hydrochloride is an inhibitor of Histamine H1 Receptor and SR-2C.
DC9002	Cimetidine	Cimetidine is a histamine-2 (H2) receptor antagonist.